Effect of dioxin exposure on serum steroid hormones in adult male
SHEN Bin1, SHI Li-li1, DONG Jing-jian1, FENG Hao1, SHEN Lin-jie1, XIANG Jing1, LI Wen-jing1, LUO Ting1, KIDO Teruhiko2, SUN Xian-liang1,2
1. Department of public health, School of Medicine, Jiaxing University, Jiaxing 314001, Zhejiang, China; 2. Faculty of Health Sciences, Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University, Kanazawa 9208640, Japan
Abstract：In order to investigate effect of dioxin exposure on serum steroid hormones in adult male, 17dioxin congeners of polychlorinated dibenzodioxins (PCDDs), polychlorinated dibenzofurans (PCDFs) and 9 steroid hormones were analyzed in serum from dioxin polluted area (n=50) and non-polluted area(n=48) by HRGC/HRMS and LC-MS/MS. The results showed that testosterone, estradiol, dihydrotestosterone (DHT), and dihydroepiandrosteron levels were significantly related to concentrations of several dioxin derivatives. Levels of DHT, Testosterone and Estradiol increased significantly with age in the dioxin polluted area adult males. Our findings suggest that dioxin exposure can lead to abnormal changes in sex hormones in adult male.
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