Biotoxicity effects and respiratory risk assessment of PCDD/Fs exposured to atmospheric particulates in Shanghai
SONG Peng-cheng1, LU Shu-yu1,2, WEI Yong-jie3, LUO Li-juan4, CHEN Xiao-qian5
1. College of Environmental Science and Engineering, Donghua University, Shanghai 201620, China; 2. Shanghai Society of Environmental Sciences, Shanghai 200003, China; 3. Chinese Research Academy of Environmental Sciences, Beijing 100012, China; 4. Shanghai Radio-Environment Supervision Agency, Shanghai 200065, China; 5. Shanghai Academy of Public Measurement, Shanghai 201203, China
Abstract：Bacterial toxicity of atmospheric particulate suspensions in residential and industrial areas was evaluated with Microtox test (Vibrio fischeri), and the toxicity effects of rats after particulate exposure were also analyzed and discussed. HRGC-HRMS was applied to study concentration level and composition characteristic of PCDD/Fs, in addition, dioxin respiratory exposure risk assessment was conducted based on the data analysis. Results showed that the acute toxicity of atmospheric particulate in industrial site was higher than those in residential site, which indicated that acute toxicity was closely related to local pollution. The bacterial toxicity results of airborne particles with different particle sizes were significantly different, which suggested that toxicant was mainly adsorbed on finer particles. Exposure experiment studies provided overwhelming evidence that pathological damage of lungs after particulate exposure was correlative with overproduction of oxidative free radical, so toxicological mechanism associated with free radicals could be used as a pathway for further in-depth study. Concentration of PCDD/Fs ranged from 0.034~1.29pg/m3 in active sampling, from 0.031~0.103pg/m3 in passive sampling, and from 0.226~4.67pg/(m2·d) in atmospheric deposition sampling respectively, with a mean concentration of 0.366pg/m3, 0.063pg/m3 and 1.82pg/(m2·d) respectively. Dominant composition characteristics of PCDD/Fs were 2,3,4,7,8-PeCDF, 2,3,4,6,7,8-HxCDF, 1,2,3,6,7,8-HxCDF, 1,2,3,4,7,8-HxCDF for active sampling, 2,3,4,7,8-PeCDF, 1,2,3,7,8-PeCDD, 2,3,7,8-TCDD, 2,3,7,8-TCDF for passive sampling, and 2,3,4,7,8-PeCDF, 1,2,3,7,8-PeCDD, 2,3,7,8-TCDD, 2,3,7,8-TCDF for atmospheric deposition sampling respectively. Maximum respiratory exposures of adult[9.74×10-2pg/(kg·d)] and children[1.28×10-1pg/(kg·d)] were lower than 0.4pg/(kg·d)-1 (maximum allowed daily intake), which indicated an acceptable level of inhalation exposure risk.
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SONG Peng-cheng, LU Shu-yu, WEI Yong-jie, LUO Li-juan, CHEN Xiao-qian. Biotoxicity effects and respiratory risk assessment of PCDD/Fs exposured to atmospheric particulates in Shanghai. CHINA ENVIRONMENTAL SCIENCECE, 2018, 38(5): 1961-1969.
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