In order to recover water resources from domestic sewage and reduce the reactor volume for subsequent treatment, aquaporin biomimetic forward osmosis membrane was used to concentrate domestic sewage. The effect of different draw solution on domestic sewage concentration and membrane fouling was explored. In the process of concentration, the volume of sewage was reduced to about 1/10 of the initial volume; while the concentrations of nitrogen and phosphorus were about 1~3 times of their initial concentrations, the concentration of organic matter and metal ions were about 4~7 times of their initial concentrations. The ratio COD/TN of sewage increased from 2.9 to 10.9, which increased the potential for biological nitrogen removal. Due to the reverse salt diffusion of the draw solution and the increase of the pollutant concentration in the feed solution, the high ionic strength affected the rejection of pollutants. Using draw solution with high concentration can cause severe scaling and fouling of the membrane surface. MgCl₂ as the draw solution can effectively alleviate the accumulation of salinity during the concentration process, and Mg²⁺ can promote microbial activity, but it could also lead to the decomposition of aquaporin.