Monolithic honeycomb molecular sieve carriers were used to prepare copper, manganese and cerium supported catalysts. The catalytic performance and stability of the catalyst were investigated by microwave-assisted catalytic combustion of VOCs (toluene, acetone, ethyl acetate). And affecting factors of catalytic activity were analyzed and temperature distribution of the bed was tested simultaneously. The removal efficiency of VOCs with an initial concentration of 200~2000mg/m³ was between 80% and 92% under conditions of microwave power 1.3kW, catalyst bed volume 300'm×300mm×300mm, reaction temperature of the fixed bed higher than 300℃, and air volume 5m³/h. Temperature was a prerequisite for the oxidative degradation of VOCs, and the effect of temperature rising on the degradation of VOCs was no longer obvious after the bed temperature exceeded 300℃. Monometallic oxides of copper, manganese and cerium and their composite oxides were main active components with spinel structure. VOCs were oxidized on the surface of the active components that followed by pseudo-first order reaction. Cu-Mn-Ce/Molecular sieve honeycomb catalyst had both high catalytic activity and good stability after six-time repetitive tests although high temperature made some changes for the structure.