新烟碱类农药呋虫胺对映体选择性研究进展

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摘要农业生产中，呋虫胺以外消旋体的形式销售和使用，在进入生态环境后出现对映体选择性降解、吸收、代谢、排泄等.不区分对映体间差异的传统风险评估给呋虫胺的合理使用与生态安全带来了诸多隐患.研究指出S-呋虫胺既是高毒体也是高活体，其生态毒性为R-呋虫胺的13.9~145.9倍，但R-呋虫胺也表现出较高的杀虫活性，且作物中优先降解，开发高比例的R体农药有利于维持杀虫活性的同时降低对非靶生物和生态环境的负效应.本文旨在综述呋虫胺对映体选择性生物活性、生态毒性及环境行为研究进展，为其科学难题的解决提供新思路，也为其科学有效管理提供理论依据.

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	刘子琪
	呼啸
	李莉
	朱峰
	袁龙飞
	李薇
	程有普
	陈增龙

关键词 ：呋虫胺, 对映体选择性, 生物活性, 生态毒理, 环境行为

Abstract：In the agricultural production, dinotefuran is sold and used in the form of racemate. Enantioselective degradation, absorption, metabolism and excretion of dinotefuran were observed in the ecological environment. Traditional risk assessments brought potential hazards to the rational use and ecological safety of dinotefuran without consideration of the differences between enantiomers. S-dinotefuran was an enantiomer with both high toxicities and activities, and its ecological toxicities were 13.9~145.9times than that of R-dinotefuran. However, R-dinotefuran also had comparable bioactivities and degraded preferentially in crops. The development of a high proportion of R-form pesticide could maintain the insecticidal potency and further reduce the negative effects to non-target organisms and ecological environment. This manuscript aimed to review the research progress on the enantioselective bioactivity, ecotoxicology, and environmental fate of dinotefuran, which will be conducive to propose novel ideas for solving the above scientific problems and further to provide theoretical foundation for effective management of dinotefuran.

Key words： dinotefuran enantioselectivity biological activity ecological toxicology environmental fate

收稿日期: 2021-02-24

PACS:

X503

基金资助:国家自然科学基金（31801771）；农业虫害鼠害综合治理研究国家重点实验室开放研究基金资助项目（IPM1919）

通讯作者: 程有普,副教授,chengyoupu@tjau.edu.cn;陈增龙,助理研究员,chenzenglong@ioz.ac.cn E-mail: chengyoupu@tjau.edu.cn;chenzenglong@ioz.ac.cn

作者简介: 刘子琪(1997-),女,黑龙江大兴安岭人,天津农学院园艺园林学院硕士研究生,中国科学院动物研究所联合培养,研究方向为农药残留与分子毒理学.发表论文5篇.

引用本文:

刘子琪, 呼啸, 李莉, 朱峰, 袁龙飞, 李薇, 程有普, 陈增龙. 新烟碱类农药呋虫胺对映体选择性研究进展[J]. 中国环境科学, 2021, 41(10): 4811-4819. LIU Zi-qi, HU Xiao, LI Li, ZHU Feng, YUAN Long-fei, LI Wei, CHENG You-pu, CHEN Zeng-long. Research progress on the enantioselectivity of a neonicotinoid pesticide dinotefuran. CHINA ENVIRONMENTAL SCIENCECE, 2021, 41(10): 4811-4819.

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http://www.zghjkx.com.cn/CN/ 或 http://www.zghjkx.com.cn/CN/Y2021/V41/I10/4811

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