Model-averaging species sensitivity distributions of perfluorooctanoic acid and its ecological risk assessment
GUAN Shuo1, JIN Zhong-wu1, DING Bing1, GU Yan-sheng2, LIU Xiao-guang1
1. Key Laboratory of River and Lake Regulation and Flood Control in the Middle and Lower Reaches of the Yangtze River of Ministry of Water Resources, Changjiang River Scientific Research Institute, Wuhan 430010, China; 2. State Key Laboratory of Biogeology and Environmental Geology, China University of Geosciences, Wuhan 430074, China
Abstract：In this study, 30 aquatic species and their associated 53 single toxicity data were collected and screened. Based on different toxicity endpoint data, an Species Sensitivity Distribution (SSD) model for perfluorooctanoic acid (PFOA) was created. In order to reduce the uncertainty introduced by model selection, the model-averaging method was employed and applied to ecological risk assessment. According to the data on lethality, growth inhibition, reproductive toxicity, and biochemical toxicity, the derived Predicted No-Effect Concentration (PNEC) values were 2.09, 0.02, 0.006, and 0.024mg/L, respectively. It is noteworthy that under PFOA exposure, the reproductive endpoint of aquatic species exhibited the highest sensitivity. Therefore, the PNEC value based on the reproductive toxicity endpoint was selected as the Aquatic Life Criteria (ALC) for PFOA. Furthermore, PFOA exposure concentration data in surface water from the Yangtze River basin were collected, and the ecological risk of surface water in the Yangtze River basin was assessed using the Hazard Quotients (HQ) method. The research results indicate that among the 12sampling sites in the Yangtze River basin, the HQ values of all surface water samples range from 0.0004 to 0.04, suggesting that the ecological risk of PFOA in the Yangtze River basin is low. The findings of this study provide important references for aquatic bioprotection and mitigating the ecological risks of PFOA in China.
[1] Lau C, Butenhoff J L, Rogers J M. The developmental toxicity of perfluoroalkyl acids and their derivatives [J]. Toxicology and Applied Pharmacology, 2004,198(2):231-241. [2] Renner R. Growing concern over perfluorinated chemicals [J]. Environmental Science & Technology, 2001,35(7):154-160. [3] Key B D, Howell R D, Criddle C S. Fluorinated organics in the biosphere [J]. Environmental Science & Technology, 1997,31(9): 2445-2454. [4] Pan C G, Ying G G, Zhao J L, et al. Spatiotemporal distribution and mass loadings of perfluoroalkyl substances in the Yangtze River of China [J]. Science of the Total Environment, 2014,493:580-587. [5] Giesy J P, Kannan K. Global distribution of perfluorooctane sulfonate in wildlife [J]. Environmental Science & Technology, 2001,35:1339-42. [6] Tao L, Kannan K, Kajiwara N, et al. Perfluorooctane sulfonate and related fluorochemicals in albatrosses, elephant seals, penguins, and polar skuas from the Southern Ocean [J]. Environmental Science & Technology, 2006,40:7642-7648. [7] Giari L F, Vincenzi S, Badini C, et al. Common carp Cyprinus carpio responses to sub-chronic exposure to perfluorooctanoic acid [J]. Environmental Science and Pollution Research, 2016,23(15):15321-15330. [8] Kadlec S M, Backe W J, Erickson R J, et al. Sublethal toxicity of 17per- and polyfluoroalkyl substances with diverse structures to Ceriodaphnia dubia, Hyalella azteca, and Chironomus dilutes [J]. Environmental Toxicology and Chemistry, 2024,43(2):359-373. [9] Cai M, Yang H, Xie Z, et al. Per-and polyfluoroalkyl substances in snow, lake, surface runoff water and coastal seawater in Fildes Peninsula, King George Island, Antarctica [J]. Journal of Hazardous Materials, 2012,209:335-342. [10] Ai S, Gao X, Wang X, et al. Exposure and tiered ecological risk assessment of phthalate esters in the surface water of Poyang Lake, China [J]. Chemosphere, 2021,262:127864. [11] 曹莹,张亚辉,闫振广,等.PFOS和PFOA的水生生物基准探讨及对中国部分水体生态风险的初步评估[J]. 生态环境学报, 2016,25(7): 1188-1194. Cao Y, Zhang Y H, Yan Z G, ZHU Yan, et al. Development of aquatic life criteria for PFOS and PFOA and preliminary assessment for the ecological risk of some water bodies in China [J]. Ecology and Environmental Sciences, 2016,25(7):1188-1194. [12] Gorrochategui E, Lacorte S, Tauler R, et al. Perfluoroalkylated substance effects in Xenopus laevis A6 kidney epithelial cells determined by ATR-FTIR spectroscopy and chemometric analysis [J]. Chemical Research in Toxicology, 2016,29(5):924-932. [13] He W, Qin N, Kong X, et al. Ecological risk assessment and priority setting for typical toxic pollutants in the water from Beijing-Tianjin- Bohai area using Bayesian matbugs calculator (BMC) [J]. Ecological Indicators, 2014,45:209-218. [14] Schwarz C J, Tillmanns A R. Improving statistical methods to derive species sensitivity distributions (WSS2019-07) [R]. Victoria, BC: Province of British Columbia, 2019. [15] Fox D R, van Dam R A, Fisher R, et al. Recent developments in species sensitivity distribution modeling [J]. Environmental Toxicology and Chemistry, 2021,40:293-308. [16] Jin X, Wang Y, Jin W, et al. Ecological risk of nonylphenol in China surface waters based on reproductive fitness [J]. Environmental Science & Technology, 2014,48:1256-1262. [17] Klimisch H J, Andreae M, Tillmann U. A systematic approach for evaluating the quality of experimental toxicological and ecotoxicological data [J]. Regulatory Toxicology and Pharmacology, 1997,25:1-5. [18] HJ 831-2022淡水水生生物水质基准推导技术指南[S]. HJ 831-2022 Technical guideline for deriving water quality criteria for freshwater organisms [S]. [19] 中国科学院中国动物志编辑委员会.中国动物志[M]. 北京:科学出版社, 2016. Editorial Committee of Fauna Sinica, Chinese Academy of Sciences. Faun Sinica [M]. Beijing: Science Press, 2016. [20] Anderson D, Burnham K, Model selection and multi-model inference [M]. Springer, 2004,10. [21] Wang Z F, Qu C K, Zhang J W, et al. Constructing model-averaging species sensitivity distributions of Phenanthrene based on reproductive fitness: Implications for assessing ecological risk in urban watershed [J]. Journal of Hazardous Materials, 2023,443:130296. [22] van Treeck R, Van Wichelen J, Wolter C. Fish species sensitivity classification for environmental impact assessment, conservation and restoration planning [J]. Science of The Total Environment, 2020,708:135173. [23] Yang S, Xu F, Wu F, et al. Development of PFOS and PFOA criteria for the protection of freshwater aquatic life in China [J]. Science of The Total Environment, 2014,470:677-683. [24] Sun W Q, Zhang X M, Qiao Y, et al. Exposure to PFOA and its novel analogs disrupts lipid metabolism in Zebrafish [J]. Ecotoxicology and Environmental Safety, 2023,259:115020. [25] Logeshwaran P, Sivaram A K, Surapaneni A, et al. Exposure to perfluorooctane sulfonate (PFOS) but not perfluorooctanoic acid (PFOA) at ppb concentration induces chronic toxicity in Daphnia carinata [J]. Science of The Total Environment. 2021,769:144577. [26] Lu G H, Ma B H, Li S, et al. Toxicological effects of perfluorooctanoic acid (PFOA) on Daphnia magna [J]. Material Science and Environmental Engineering, 2016:559-564. [27] Ji K, Kim Y, Oh S, et al. Toxicity of perfluorooctane sulfonic acid and perfluorooctanoic acid on freshwater macroinvertebrates (Daphnia magna and Moina macrocopa) and fish (Oryzias latipes) [J]. Environmental Toxicology and Chemistry, 2008,27(10):2159-2168. [28] Razak M R, Aris A Z, Zainuddin A H, et al. Acute toxicity and risk assessment of perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) in tropical cladocerans Moina micrura [J]. Chemosphere, 2023,313:137377. [29] Le T T Y, Peijnenburg W J G M. Modeling toxicity of mixtures of perfluorooctanoic acid and triazoles (triadimefon and paclobutrazol) to the benthic cladoceran Chydorus sphaericus [J]. Environmental Science & Technology, 2013,47(12):6621-6629. [30] Soucek D J, Dorman R A, Pulster E L, et al. Perfluorooctane sulfonate adversely affects a mayfly (Neocloeon triangulifer) at environmentally realistic concentrations [J]. Environmental Science & Technology Letters, 2023,10(3):254-259. [31] Zhang L, Niu J, Li Y, et al. Evaluating the sub-lethal toxicity of PFOS and PFOA using rotifer Brachionus calyciflorus [J]. Environmental Pollution, 2013,180:34-40. [32] Yuan Z, Zhang J, Zhang Y, et al. The effect of perfluorooctanoic acid on the planarian Dugesia japonica [J]. Polish Journal of Environmental Studies, 2015,24(2):801-807. [33] Giari L, Vincenzi F, Badini S, et al. Common carp Cyprinus carpio responses to sub-chronic exposure to perfluorooctanoic acid [J]. Environmental Science and Pollution Research, 2016,23(15):15321-15330. [34] Jantzen C E, Annunziato K M, Cooper K R. Behavioral, morphometric, and gene expression effects in adult zebrafish (Danio rerio) embryonically exposed to PFOA, PFOS, and PFNA [J]. Aquatic Toxicology, 2016,180:123-130. [35] Benninghoff A D, Orner G A, Buchner C H, et al. Promotion of hepatocarcinogenesis by perfluoroalkyl acids in rainbow trout [J]. Toxicological Sciences, 2012,125(1):69-78. [36] Oh J H, Moon H B, Choe E S. Alterations in differentially expressed genes after repeated exposure to perfluorooctanoate and perfluorooctane sulfonate in liver of Oryzias latipes [J]. Archives of Environmental Contamination and Toxicology, 2013,64(3):475-483. [37] Yang H B, Zhou Z Y, Tang Y, et al. Antioxidant defence system is responsible for the toxicological interactions of mixtures: a case study on PFOS and PFOA in Daphnia magna [J]. Science of The Total Environment, 2019,667:435-443. [38] McCarthy C J, Roark S A, Wright D, et al. Toxicological response of Chironomus dilutus in single chemical and binary mixture exposure experiments with 6 perfluoralkyl substances [J]. Environmental Toxicology and Chemistry, 2021,40(8):2319-2333. [39] Bartlett A J, De Silva A O, Schissler D M, et al. Lethal and sublethal toxicity of perfluorooctanoic acid (PFOA) in chronic tests with Hyalella azteca (amphipod) and early-life stage tests with Pimephales promelas (fathead minnow) [J]. Ecotoxicology and Environmental Safety, 2021,207:111250. [40] Zhang L, Niu J, Wang Y, et al. Chronic effects of PFOA and PFOS on sexual reproduction of freshwater rotifer Brachionus calyciflorus [J]. Chemosphere, 2014,114:114-120. [41] Zhang J, Shao X, Zhao B, et al. Neurotoxicity of perfluorooctanoic acid and post-exposure recovery due to blueberry anthocyanins in the planarians Dugesia japonica [J]. Environmental Pollution, 2020,263:114471. [42] Pietrini F, Passatore L, Fischetti E, et al. Evaluation of morpho- physiological traits and contaminant accumulation ability in Lemna minor L. treated with increasing perfluorooctanoic acid (PFOA) concentrations under laboratory conditions [J]. Science of The Total Environment, 2019,695:133828. [43] Hagenaars A, Vergauwen L, Benoot D, et al. Mechanistic toxicity study of perfluorooctanoic acid in zebrafish suggests mitochondrial dysfunction to play a key role in PFOA toxicity [J]. Chemosphere, 2013,91(6):844-856. [44] Kang J S, Ahn T G, and Park J W. Perfluorooctanoic acid (PFOA) and perfluooctane sulfonate (PFOS) induce different modes of action in reproduction to Japanese medaka (Oryzias latipes) [J]. Journal of Hazardous Materials, 2019,368:97-103. [45] Stefani F, Rusconi M, Valsecchi S, et al. Evolutionary ecotoxicology of perfluoralkyl substances (PFASs) inferred from multigenerational exposure: a case study with Chironomus riparius (Diptera, Chironomidae) [J]. Aquatic Toxicology, 2014,156:41-51. [46] Wu Y, Xiong Q, Wang B, et al. Screening of structural and functional alterations in duckweed (Lemna minor) induced by per- and polyfluoroalkyl substances (PFASs) with FTIR spectroscopy [J]. Environmental Pollution, 2023,317:120671. [47] 3M Company. Information on perfluorooctanoic acid and supplemental information on perfluorooctane sulfonates and related compounds [R]. Boston: 3M Company, 2000. [48] Zhao Z L, Zheng X Y, Han Z S, et al. Response mechanisms of Chlorella sorokiniana to microplastics and PFOA stress: photosynthesis, oxidative stress, extracellular polymeric substances and antioxidant system [J]. Chemosphere, 2023,323:138256. [49] Mao W, Li M, Xue X, et al. Bioaccumulation and toxicity of perfluorooctanoic acid and perfluorooctane sulfonate in marine algae Chlorella sp. [J]. Science of The Total Environment, 2023,870:161882. [50] Hu C, Luo Q, Huang Q. Ecotoxicological effects of perfluorooctanoic acid on freshwater microalgae Chlamydomonas reinhardtii and Scenedesmus obliquus [J]. Environmental Toxicology and Chemistry, 2014,33(5):1129-1134. [51] Feng M, He Q, Meng L, et al. Evaluation of single and joint toxicity of perfluorooctane sulfonate, perfluorooctanoic acid, and copper to Carassius auratus using oxidative stress biomarkers [J]. Aquatic Toxicology, 2015,161:108-116. [52] Kim W K, Lee S K, and Jung J. Integrated assessment of biomarker responses in common carp (Cyprinus carpio) exposed to perfluorinated organic compounds [J]. Journal of Hazardous Materials, 2010,180(1-3):395-400. [53] Wei Y, Dai J, Liu M, et al. Estrogen-like properties of perfluorooctanoic acid as revealed by expressing hepatic estrogen-responsive genes in rare minnows (Gobiocypris rarus) [J]. Environmental Toxicology and Chemistry, 2007,26(11):2440-2447. [54] Tornabene B J, Chislock M F, Gannon M E, et al. Relative acute toxicity of three per- and polyfluoroalkyl substances on nine species of larval amphibians [J]. Integrated Environmental Assessment and Management, 2021,17(4):684-689. [55] Xu D, Li C, Chen H, et al. Cellular response of freshwater green algae to perfluorooctanoic acid toxicity [J]. Ecotoxicology and Environmental Safety, 2013,88:103-107. [56] Gredelj A, Barausse A, Grechi L, et al. Deriving predicted no-effect concentrations (PNECs) for emerging contaminants in the River Po, Italy, using three approaches: assessment factor, species sensitivity distribution and AQUATOX ecosystem modelling [J]. Environment International, 2018,119:66-78. [57] Heads of EPAs Australia and New Zealand (HEPA). PFAS national environmental management plan. Version 2.0[EB/OL]. https://www.dcceew.gov.au/environment/protection/publications/pfas-nemp-2#dcceew-main. [58] US Environmental Protection Agency (US EPA). Aquatic life ambient water quality criteria for perfluorooctanoic acid (PFOA) [EB/OL]. https://www.epa.gov/wqc/aquatic-life-criteria-perfluorooctanoic-acid-pfoa. [59] 李珍.长江中游地区湖泊全氟化合物的污染特征及生态风险评估[D]. 北京:中国科学院大学, 2019. Li Z. Distribution and risk assessment of perfluoroalkyl substances in lakes from the middle reach of Yangtze River, China [D]. Beijing: University of Chinese Academy of Sciences, 2019. [60] Sun Z Y, Zhang C J, Yan H, et al. Spatiotemporal distribution and potential sources of perfluoroalkyl acids in Huangpu River, Shanghai, China [J]. Chemosphere, 2017,174:127-135. [61] Guo C S, Zhang Y, Zhao X, et al. Distribution, source characterization and inventory of perfluoroalkyl substances in Taihu Lake, China [J]. Chemosphere, 2015,127:201-207. [62] So M K, Miyake Y, Yeung W Y, et al. Perfluorinated compounds in the Pearl River and Yangtze River of China [J]. Chemosphere, 2007,68(11):2085-2095. [63] 金一和,丁梅,翟成,等.长江三峡库区江水和武汉地区地面水中PFOS和PFOA污染现状调查[J]. 生态环境, 2006,3:486-489. Jin Y H, Ding M, Zhai C, et al. An investigation of the PFOS and PFOA pollution in Three Gorges Reservoir areas of the Yangtze River and surface water of Wuhan areas [J]. Ecology and Environment, 2006, 3:486-489. [64] Chen C S. Ecological risk assessment for aquatic species exposed to contaminants in Keelung River, Taiwan [J]. Chemosphere, 2005,61, 1142-1158.
