Distribution characteristics and influencing factors of antibiotic resistance genes in inland rivers of Northwest China
XING Yue1,2, ZHANG Wen1, CHENG Yan2, CHENG Gang2,3, HU Hai-yang4
1. College of Chemistry and Chemical Engineering, Xinjiang Agricultural University, Urumqi 830052, China; 2. Xinjiang Research Institute of Environmental Protection, Urumqi 830012, China; 3. College of Life Sciences, Shangrao Normal University, Shangrao 334003, China; 4. College of Water Conservancy and Civil Engineering, Xinjiang Agricultural University, Urumqi 830052, China
Abstract：The distribution characteristics of antibiotic resistance genes (ARGs) and bacterial community structure in surface water of Y River Basin were analyzed based on metagenomics. The relationship between ARGs and environmental factors and bacterial communities was investigated. The results showed that 21 types of ARGs and 1295 subtypes of ARGs, 6resistance mechanisms were detected in the surface water of Y River basin, among which multidrug was the main type of ARGs, macB was the dominant subtype of ARGs, and antibiotic effluents were the main resistance mechanisms.Bacteria were detected at 160 phylum levels and 4149 genus levels, respectively, among which Proteobacteria is the dominant bacteria phylum, Liminohabitans and others are the dominant bacteria genera. The correlation analysis showed that TOC, DOC and CODMn were significantly correlated with various ARGs subtypes(P<0.05); Some genera, such as Flavobacterium, Polaromonas, and Nocardioides, were significantly associated with multiple ARGs (P<0.05) and involved multiple type and resistance mechanisms of ARGs .This study aims to provide data support for ARGs distribution characteristics of typical inland river environment in northwest arid region.
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