Abstract：In this review, the pollution status of atmospheric microplastics was introduced, with a focus on its distribution characteristics, such as abundance, composition, shape, and size, as well as the evidence of microplastics in human respiratory system. Further, the potential health effects of respiratory exposure to microplastics were summarized. Lastly, some prospects were proposed for future research, including emphasizing and improving the knowledge on potential harmful effects of microplastics or smaller sized nanoplastics, and strengthening the exposure characteristics analysis, health risk assessment, and the toxicological mechanistic investigations.
Thompson R C, Olsen Y, Mitchell R P, et al. Lost at sea:where is all the plastic? [J]. Science, 2004,304(5672):838.
[2]
Auta H S, Emenike C U, Fauziah S H. Distribution and importance of microplastics in the marine environment:A review of the sources, fate, effects, and potential solutions [J]. Environment International, 2017, 102:165-176.
[3]
Amato-Lourenço L F, Dos S G L, de Weger L A, et al. An emerging class of air pollutants:Potential effects of microplastics to respiratory human health? [J]. Science of the Total Environment, 2020,749:141676.
[4]
Zhang Y, Kang S, Allen S, et al. Atmospheric microplastics:A review on current status and perspectives [J]. Earth-Science Reviews, 2020,203:103118.
[5]
Pironti C, Ricciardi M, Motta O, et al. Microplastics in the environment:intake through the food web, human exposure and toxicological effects [J]. Toxics, 2021,9(9):224.
[6]
Benson N U, Bassey D E, Palanisami T. COVID pollution:impact of COVID-19pandemic on global plastic waste footprint [J]. Heliyon, 2021,7(2):e06343.
[7]
Hu T, Shen M, Tang W. Wet wipes and disposable surgical masks are becoming new sources of fiber microplastic pollution during global COVID-19[J]. Environmental Science and Pollution Research International, 2022,29(1):284-292.
[8]
Dris R, Gasperi J, Saad M, et al. Synthetic fibers in atmospheric fallout:A source of microplastics in the environment? [J]. Marine Pollution Bulletin, 2016,104(1/2):290-293.
[9]
Klein M, Fischer E K. Microplastic abundance in atmospheric deposition within the Metropolitan area of Hamburg, Germany [J]. Science of the Total Environment, 2019,685:96-103.
[10]
郭梓萌,崔小梅,陈均玉,等.大气中微塑料的研究进展[J]. 环境化学, 2023,43(12):1-14. Guo Z M, Cui X M, Chen J Y, et al. Research progress on microplastics in the atmosphere [J]. Environmental Chemistry, 2023, 43(12):1-14.
[11]
Allen S, Allen D, Moss K, et al. Examination of the ocean as a source for atmospheric microplastics [J]. Public Library of Science One, 2020,15(5):e0232746.
[12]
Cai L, Wang J, Peng J, et al. Characteristic of microplastics in the atmospheric fallout from Dongguan city, China:preliminary research and first evidence [J]. Environmental Science and Pollution Research International, 2017,24(32):24928-24935.
[13]
Qian Z, Tian C G, Luo Y M. Various forms and deposition fluxes of microplastics identified in the coastal urban atmosphere [J]. Chinese Science Bulletin, 2017,62(33):3902-3909.
[14]
Allen S, Allen D, Phoenix V R, et al. Atmospheric transport and deposition of microplastics in a remote mountain catchment [J]. Nature Geoscience, 2019,12(5):339-344.
[15]
Dris R, Gasperi J, Mirande C, et al. A first overview of textile fibers, including microplastics, in indoor and outdoor environments [J]. Environmental Pollution, 2017,221:453-458.
[16]
Liu K, Wang X, Fang T, et al. Source and potential risk assessment of suspended atmospheric microplastics in Shanghai [J]. Science of the Total Environment, 2019,675:462-471.
[17]
Liu C, Li J, Zhang Y, et al. Widespread distribution of PET and PC microplastics in dust in urban China and their estimated human exposure [J]. Environment International, 2019,128:116-124.
Hartmann N B, Hüffer T, Thompson R C, et al. Are we speaking the same language? Recommendations for a definition and categorization framework for plastic debris [J]. Environmental Science and Technology, 2019,53(3):1039-1047.
[20]
Wright S L, Ulke J, Font A, et al. Atmospheric microplastic deposition in an urban environment and an evaluation of transport [J]. Environment International, 2020,136:105411.
[21]
Yukioka S, Tanaka S, Nabetani Y, et al. Occurrence and characteristics of microplastics in surface road dust in Kusatsu (Japan), Da Nang (Vietnam), and Kathmandu (Nepal) [J]. Environmental Pollution, 2020,256:113447.
[22]
Stanton T, Johnson M, Nathanail P, et al. Freshwater and airborne textile fibre populations are dominated by ‘natural’, not microplastic, fibres [J]. Science of the Total Environment, 2019,666:377-389.
[23]
Hidalgo-Ruz V, Gutow L, Thompson R C, et al. Microplastics in the marine environment:a review of the methods used for identification and quantification [J]. Environmental Science and Technology, 2012, 46(6):3060-3075.
[24]
Dris R, Gasperi J, Rocher V, et al. Microplastic contamination in an urban area:a case study in Greater Paris [J]. Environmental Chemistry, 2015,12(5):592.
[25]
Dehghani S, Moore F, Akhbarizadeh R. Microplastic pollution in deposited urban dust, Tehran metropolis, Iran [J]. Environmental Science and Pollution Research International, 2017,24(25):20360-20371.
[26]
Abbasi S, Keshavarzi B, Moore F, et al. Distribution and potential health impacts of microplastics and microrubbers in air and street dusts from Asaluyeh County, Iran [J]. Environmental Pollution, 2019, 244:153-164.
[27]
O'Brien S, Okoffo E D, O'Brien J W, et al. Airborne emissions of microplastic fibres from domestic laundry dryers [J]. Science of the Total Environment, 2020,747:141175.
[28]
Wu P, Huang J, Zheng Y, et al. Environmental occurrences, fate, and impacts of microplastics [J]. Ecotoxicology and Environmental Safety, 2019,184:109612.
[29]
Frias J, Nash R. Microplastics:Finding a consensus on the definition [J]. Marine Pollution Bulletin, 2019,138:145-147.
[30]
Li Y, Shao L, Wang W, et al. Airborne fiber particles:Types, size and concentration observed in Beijing [J]. Science of the Total Environment, 2020,705:135967.
[31]
张雅珊,陈宗耀,马伟芳.微塑料的迁移转化及其生态风险研究进展[J]. 化工进展, 2022,41(11):6080-6098. Zhang Y S, Chen Z Y, Ma W F. Research progress on the migration and transformation of microplastics and environmental risks [J]. Chemical Industry and Engineering Progress, 2022,41(11):6080-6098.
[32]
陈璇,章家恩,危晖.环境微塑料的迁移转化及生态毒理学研究进展[J]. 生态毒理学报, 2021,16(6):70-86. Chen X, Zhang J E, Wei H. Research progress and prospect on transportation, transformation and ecotoxicology of microplastics in environment [J]. Asian Journal of Ecotoxicology, 2021,16(6):70-86.
[33]
Barletta M, Lima A, Costa M F. Distribution, sources and consequences of nutrients, persistent organic pollutants, metals and microplastics in South American estuaries [J]. Science of the Total Environment, 2019,651(Pt 1):1199-1218.
[34]
Yu F, Yang C, Zhu Z, et al. Adsorption behavior of organic pollutants and metals on micro/nanoplastics in the aquatic environment [J]. Science of the Total Environment, 2019,694:133643.
[35]
Mao R, Lang M, Yu X, et al. Aging mechanism of microplastics with UV irradiation and its effects on the adsorption of heavy metals [J]. Journal of Hazardous Materials, 2020,393:122515.
[36]
Prata J C. Airborne microplastics:Consequences to human health? [J]. Environmental Pollution, 2018,234:115-126.
[37]
徐力波,胡敏,贾薇茜,等.大气环境中微塑料分布与迁移及生态环境影响研究进展[J]. 科学通报, 2022,67(30):3565-3579. Xu L B, Hu M, Jia W Q, et al. Distribution and transport of atmospheric microplastics and the environmental impacts:A review [J]. Chinese Science Bulletin, 2022,67(30):3565-3579.
[38]
Romera-Castillo C, Pinto M, Langer T M, et al. Dissolved organic carbon leaching from plastics stimulates microbial activity in the ocean [J]. Nature Communications, 2018,9(1):1430.
[39]
Vianello A, Jensen R L, Liu L, et al. Simulating human exposure to indoor airborne microplastics using a Breathing Thermal Manikin [J]. Scientific Reports, 2019,9(1):8670.
[40]
Cox K D, Covernton G A, Davies H L, et al. Human consumption of microplastics [J]. Environmental Science and Technology, 2019,53(12):7068-7074.
[41]
Rotchell J M, Jenner L C, Chapman E, et al. Detection of microplastics in human saphenous vein tissue using μFTIR:A pilot study [J]. Public Library of Science One, 2023,18(2):e0280594.
[42]
Amato-Lourenço L F, Carvalho-Oliveira R, Júnior G R, et al. Presence of airborne microplastics in human lung tissue [J]. Journal of Hazardous Materials, 2021,416:126124.
[43]
Ibrahim Y S, Tuan A S, Azmi A A, et al. Detection of microplastics in human colectomy specimens [J]. Open Access Journal of Gastroenterology and Hepatology, 2021,5(1):116-121.
[44]
Ragusa A, Svelato A, Santacroce C, et al. Plasticenta:First evidence of microplastics in human placenta [J]. Environment International, 2021, 146:106274.
[45]
Schwabl P, Köppel S, Königshofer P, et al. Detection of various microplastics in human stool:A prospective case series [J]. Annals of Internal Medicine, 2019,171(7):453-457.
[46]
Liu S, Lin G, Liu X, et al. Detection of various microplastics in placentas, meconium, infant feces, breastmilk and infant formula:A pilot prospective study [J]. Science of the Total Environment, 2022, 854:158699.
[47]
Jenner L C, Rotchell J M, Bennett R T, et al. Detection of microplastics in human lung tissue using μFTIR spectroscopy [J]. Science of the Total Environment, 2022,831:154907.
[48]
Jiang Y, Han J, Na J, et al. Exposure to microplastics in the upper respiratory tract of indoor and outdoor workers [J]. Chemosphere, 2022,307(Pt 3):136067.
[49]
Huang S, Huang X, Bi R, et al. Detection and analysis of microplastics in human sputum [J]. Environmental Science and Technology, 2022,56(4):2476-2486.
[50]
Baeza-Martínez C, Olmos S, González-Pleiter M, et al. First evidence of microplastics isolated in European citizens' lower airway [J]. Journal of Hazardous Materials, 2022,438:129439.
[51]
Zhao B, Rehati P, Yang Z, et al. The potential toxicity of microplastics on human health [J]. Science of the Total Environment, 2024,912:168946.
[52]
Song Y, Li X, Du X. Exposure to nanoparticles is related to pleural effusion, pulmonary fibrosis and granuloma [J]. European Respiratory Journal, 2009,34(3):559-567.
[53]
Burkhart J, Jones W, Porter D W, et al. Hazardous occupational exposure and lung disease among nylon flock workers [J]. American Journal of Industrial Medicine, 1999,Suppl 1:145-146.
[54]
Eschenbacher W L, Kreiss K, Lougheed M D, et al. Nylon flock-associated interstitial lung disease [J]. American Journal of Respiratory and Critical Care Medicine, 1999,159(6):2003-2008.
[55]
Barroso E, Ibañez M D, Aranda F I, et al. Polyethylene flock-associated interstitial lung disease in a Spanish female [J]. European Respiratory Journal, 2002,20(6):1610-1612.
[56]
Atis S, Tutluoglu B, Levent E, et al. The respiratory effects of occupational polypropylene flock exposure [J]. European Respiratory Journal, 2005,25(1):110-117.
[57]
Pimentel J C, Avila R, Lourenço A G. Respiratory disease caused by synthetic fibres:a new occupational disease [J]. Thorax, 1975,30(2):204-219.
[58]
Kumar R, Manna C, Padha S, et al. Micro(nano)plastics pollution and human health:How plastics can induce carcinogenesis to humans? [J]. Chemosphere, 2022,298:134267.
[59]
Mastrangelo G, Fedeli U, Fadda E, et al. Lung cancer risk in workers exposed to poly(vinyl chloride) dust:a nested case-referent study [J]. Occupational and Environmental Medicine, 2003,60(6):423-428.
[60]
Wright S L, Kelly F J. Plastic and human health:A micro issue? [J]. Environmental Science and Technology, 2017,51(12):6634-6647.
[61]
Fan Z, Xiao T, Luo H, et al. A study on the roles of long non-coding RNA and circular RNA in the pulmonary injuries induced by polystyrene microplastics [J]. Environment International, 2022,163:107223.
[62]
Wu Y, Yao Y, Bai H, et al. Investigation of pulmonary toxicity evaluation on mice exposed to polystyrene nanoplastics:The potential protective role of the antioxidant N-acetylcysteine [J]. Science of the Total Environment, 2023,855:158851.
[63]
Zarus G M, Muianga C, Hunter C M, et al. A review of data for quantifying human exposures to micro and nanoplastics and potential health risks [J]. Science of the Total Environment, 2021,756:144010.
[64]
Brown D M, Wilson M R, MacNee W, et al. Size-dependent proinflammatory effects of ultrafine polystyrene particles:a role for surface area and oxidative stress in the enhanced activity of ultrafines [J]. Toxicology and Applied Pharmacology, 2001,175(3):191-199.
[65]
Lim D, Jeong J, Song K S, et al. Inhalation toxicity of polystyrene micro(nano)plastics using modified OECD TG 412[J]. Chemosphere, 2021,262:128330.
[66]
Li Y, Shi T, Li X, et al. Inhaled tire-wear microplastic particles induced pulmonary fibrotic injury via epithelial cytoskeleton rearrangement [J]. Environment International, 2022,164:107257.
[67]
Lu K, Lai K P, Stoeger T, et al. Detrimental effects of microplastic exposure on normal and asthmatic pulmonary physiology [J]. Journal of Hazardous Materials, 2021,416:126069.
[68]
Huang J, Dong G, Liang M, et al. Toxicity of micro(nano)plastics with different size and surface charge on human nasal epithelial cells and rats via intranasal exposure [J]. Chemosphere, 2022,307(Pt 4):136093.
[69]
Zha H, Xia J, Li S, et al. Airborne polystyrene microplastics and nanoplastics induce nasal and lung microbial dysbiosis in mice [J]. Chemosphere, 2023,310:136764.
[70]
Woo J H, Seo H J, Lee J Y, et al. Polypropylene nanoplastic exposure leads to lung inflammation through p38-mediated NF-κB pathway due to mitochondrial damage [J]. Particle and Fibre Toxicology, 2023, 20(1):2.
[71]
Cary C M, Seymore T N, Singh D, et al. Single inhalation exposure to polyamide micro and nanoplastic particles impairs vascular dilation without generating pulmonary inflammation in virgin female Sprague Dawley rats [J]. Particle and Fibre Toxicology, 2023,20(1):16.
[72]
Tang J, Bu W, Hu W, et al. Ferroptosis is involved in sex-specific small intestinal toxicity in the offspring of adult mice exposed to polystyrene nanoplastics during pregnancy [J]. American Chemical Society Nano, 2023,17(3):2440-2449.
[73]
Xu M, Halimu G, Zhang Q, et al. Internalization and toxicity:A preliminary study of effects of nanoplastic particles on human lung epithelial cell [J]. Science of the Total Environment, 2019,694:133794.
[74]
Dong C D, Chen C W, Chen Y C, et al. Polystyrene microplastic particles:In vitro pulmonary toxicity assessment [J]. Journal of Hazardous Materials, 2020,385:121575.
[75]
Goodman K E, Hare J T, Khamis Z I, et al. Exposure of human lung cells to polystyrene microplastics significantly retards cell proliferation and triggers morphological changes [J]. Chemical Research In Toxicology, 2021,34(4):1069-1081.
[76]
Yang S, Cheng Y, Chen Z, et al. In vitro evaluation of nanoplastics using human lung epithelial cells, microarray analysis and co-culture model [J]. Ecotoxicology and Environmental Safety, 2021,226:112837.
[77]
Jeon M S, Kim J W, Han Y B, et al. Polystyrene microplastic particles induce autophagic cell death in BEAS-2B human bronchial epithelial cells [J]. Environmental Toxicology, 2023,38(2):359-367.
[78]
Lim S L, Ng C T, Zou L, et al. Targeted metabolomics reveals differential biological effects of nanoplastics and nanoZnO in human lung cells [J]. Nanotoxicology, 2019,13(8):1117-1132.
[79]
Annangi B, Villacorta A, López-Mesas M, et al. Hazard assessment of polystyrene nanoplastics in primary human nasal epithelial cells, focusing on the autophagic effects [J]. Biomolecules, 2023,13(2):220.
[80]
Roshanzadeh A, Park S, Ganjbakhsh S E, et al. Surface charge-dependent cytotoxicity of plastic nanoparticles in alveolar cells under cyclic stretches [J]. Nano letters, 2020,20(10):7168-7176.
[81]
Zhang H, Zhang S, Duan Z, et al. Pulmonary toxicology assessment of polyethylene terephthalate nanoplastic particles in vitro [J]. Environment International, 2022,162:107177.
[82]
Halimu G, Zhang Q, Liu L, et al. Toxic effects of nanoplastics with different sizes and surface charges on epithelial-to-mesenchymal transition in A549cells and the potential toxicological mechanism [J]. Journal of Hazardous Materials, 2022,430:128485.
[83]
Paget V, Dekali S, Kortulewski T, et al. Specific uptake and genotoxicity induced by polystyrene nanobeads with distinct surface chemistry on human lung epithelial cells and macrophages [J]. Public Library of Science One, 2015,10(4):e0123297.
[84]
Xia T, Kovochich M, Liong M, et al. Cationic polystyrene nanosphere toxicity depends on cell-specific endocytic and mitochondrial injury pathways [J]. American Chemical Society Nano, 2008,2(1):85-96.
[85]
Li X, Zhang T, Lv W, et al. Intratracheal administration of polystyrene microplastics induces pulmonary fibrosis by activating oxidative stress and Wnt/β-catenin signaling pathway in mice [J]. Ecotoxicology and Environmental Safety, 2022,232:113238.
