臭氧和PM<sub>2.5</sub>对慢阻肺死亡影响及气温修饰效应

摘要
图/表
参考文献
相关文章 (15)

全文: PDF (573 KB) HTML (0 KB)
输出: BibTeX | EndNote (RIS)

摘要采用广义相加模型评估臭氧和细颗粒物（PM_2.5）暴露对2008~2017年上海浦东居民慢性阻塞性肺疾病（COPD）死亡的超额危险度（ER）和寿命损失年（YLL）的影响.结果表明：臭氧污染集中在4~6月，PM_2.5污染集中在12月、1~2月，10a间臭氧浓度逐年增加，PM_2.5有小幅下降；在最大滞后效应下，臭氧每增加10μg/m³，ER和YLL分别为1.34%（95% CI：0.57%~2.12%）和54.98（95% CI：16.36~106.41）人·a；PM_2.5每增加10μg/m³，两者分别为2.66%（95% CI：1.54%~3.79%）和130.92（95% CI：42.47~274.28）人·a；臭氧对男性和<85岁人群影响显著，PM_2.5对女性和³85岁人群影响显著；暖季时臭氧暴露相关的COPD死亡风险更高，冷季时PM_2.5暴露相关的COPD死亡风险更高.臭氧和PM_2.5致COPD死亡的影响可能因气温水平而异.

	服务

	把本文推荐给朋友
	加入我的书架
	加入引用管理器
	E-mail Alert
	RSS
	作者相关文章
	周骥
	付世华
	彭丽
	杨丹丹
	杨丝絮
	周弋
	许建明
	叶晓芳

关键词 ：臭氧, PM_2.5, 慢性阻塞性肺疾病, 死亡, 效果修饰

Abstract：Generalized additive models were used to evaluate the effects of ozone and fine particulate matter (PM_2.5) in Pudong, Shanghai from 2008 to 2017 on the excess risk (ER) and years of life lost (YLL) of chronic obstructive pulmonary disease (COPD) deaths. The results showed that: (1) Ozone pollution was extensively serious during April to June, PM_2.5 pollution was concentrated in December, January, and February; Ozone concentration increased and PM_2.5 decreased slightly in the past 10 years. (2) Under the maximum lag effect, for every 10μg/m³ increase in ozone, ER and YLL were 1.34% (95% confidence interval, 95%CI: 0.57%~2.12%) and 54.98 (95%CI: 16.36~106.41) person-years respectively, and each 10μg/m³ increase in PM_2.5 were 2.66% (95%CI: 1.54%~3.79%) and 130.92 (95%CI: 42.47~274.28) person-years, respectively. (3) Ozone leads to an increase of COPD deaths in males and people <85y, and PM_2.5 leads to an increase of COPD deaths in females and people ³85y. (4) The risk of ozone-related COPD death is higher in the warm season and the risk of PM_2.5-related COPD death is higher in the cold season. In conclusion, the effects of COPD deaths caused by ozone and PM_2.5 may vary by temperature level.

Key words： ozone fine particulate matter chronic obstructive pulmonary disease death effect modification

收稿日期: 2021-04-09

PACS:

X171.5

基金资助:国家自然科学基金资助项目（41805087）

通讯作者: 叶晓芳,高级工程师,tideye@163.com E-mail: tideye@163.com

作者简介: 周骥(1985-),男,江苏东台人,高级工程师,博士,主要从事空气污染和极端天气对健康的影响研究.发表论文30余篇.

引用本文:

周骥, 付世华, 彭丽, 杨丹丹, 杨丝絮, 周弋, 许建明, 叶晓芳. 臭氧和PM_2.5对慢阻肺死亡影响及气温修饰效应[J]. 中国环境科学, 2021, 41(12): 5904-5911. ZHOU Ji, FU Shi-hua, PENG Li, YANG Dan-dan, YANG Si-xu, ZHOU Yi, XU Jian-ming, YE Xiao-fang. Effect of ozone and PM_2.5 on chronic obstructive pulmonary disease deaths and the effect modification by the air temperature. CHINA ENVIRONMENTAL SCIENCECE, 2021, 41(12): 5904-5911.

链接本文:

http://www.zghjkx.com.cn/CN/ 或 http://www.zghjkx.com.cn/CN/Y2021/V41/I12/5904

[1]	Chen C, Liu X, Wang X, et al. Risk of temperature, humidity and concentrations of air pollutants on the hospitalization of AECOPD[J]. PloS one, 2019,14(11):e225307.
[2]	Weichenthal S, Crouse D L, Pinault L, et al. Oxidative burden of fine particulate air pollution and risk of cause-specific mortality in the Canadian Census Health and Environment Cohort (CanCHEC)[J]. Environmental Research, 2016,146:92-99.
[3]	Ansari M, Ehrampoush M H. Meteorological correlates and AirQ(+) health risk assessment of ambient fine particulate matter in Tehran, Iran[J]. Environmental Research, 2019,170:141-150.
[4]	黄丽坤,徐媛媛,王广智,等.哈尔滨市大气细颗粒物污染特征及其毒性效应[J]. 中国环境科学, 2019,39(12):5326-5332. Huang L K, Xu Y Y, Wang G Z, et al. Study on pollution characteristics and toxic effects of fine particulate matter in Harbin, China[J]. China Environmental Science, 2019,39(12):5326-5332.
[5]	邢颀颂,梁刚,武美琼,等.不同城市PM2.5对易感小鼠线粒体损伤的影响[J]. 中国环境科学, 2019,39(12):5319-5325. Xing X S, Liang G, Wu M Q, et al. Effects of PM2.5 from different cities on mitochondrial injury in susceptible mice[J]. China Environmental Science, 2019,39(12):5319-5325.
[6]	Yang L, Wang W C, Lung S C, et al. Polycyclic aromatic hydrocarbons are associated with increased risk of chronic obstructive pulmonary disease during haze events in China[J]. Science of the Total Environment, 2017,574:1649-1658.
[7]	庄加玮,刁永发,楚明浩,等.可吸入颗粒物在不同阻塞性呼吸道内运动与沉积特性[J]. 中国环境科学, 2021,41(7):3349-3359. Zhuang J W, Diao Y F, Chu M H, et al. Transport and deposition characteristics of inhalable particulate matters in different obstructive airways[J]. China Environmental Science, 2021,41(7):3349-3359.
[8]	Anenberg S C, Henze D K, Tinney V, et al. Estimates of the Global Burden of Ambient[Formula: see text], Ozone, and[Formula: see text] on Asthma Incidence and Emergency Room Visits[J]. Environ Health Perspect, 2018,126(10):107004.
[9]	Backus G S, Howden R, Fostel J, et al. Protective role of interleukin- 10 in ozone-induced pulmonary inflammation[J]. Environmental Health Perspectives, 2010,118(12):1721-1727.
[10]	Baek J, Kash B A, Xu X, et al. Association between Ambient Air Pollution and Hospital Length of Stay among Children with Asthma in South Texas[J]. International journal of environmental research and public health, 2020,17(11):3812.
[11]	Kim S, Kim E, Kim W J. Health effects of ozone on respiratory diseases[J]. Tuberculosis and Respiratory Diseases, 2020,83(Supple 1):S6-S11.
[12]	Alanazi A, Al Enezi F, Alqahtani M M, et al. Effects of passive smoking on students at college of applied medical sciences, King Saud Bin Abdulaziz University for Health Sciences, Riyadh[J]. Journal of Natural Science, Biology, and Medicine, 2015,6(1):100-105.
[13]	Shah P L, Herth F J, van Geffen W H, et al. Lung volume reduction for emphysema[J]. The Lancet. Respiratory Medicine, 2017,5(2):147- 156.
[14]	Fu S, Wang B, Zhou J, et al. Meteorological factors, governmental responses and COVID-19: Evidence from four European countries[J]. Environmental Research, 2021,194:110596.
[15]	Meng Y, Lu Y, Xiang H, et al. Short-term effects of ambient air pollution on the incidence of influenza in Wuhan, China: A time-series analysis[J]. Environmental Research, 2021,192:110327.
[16]	Hao J, Yang Z, Huang S, et al. The association between short-term exposure to ambient air pollution and the incidence of mumps in Wuhan, China: A time-series study[J]. Environmental Research, 2019,177:108660.
[17]	Qiu H, Zhu X, Wang L, et al. Attributable risk of hospital admissions for overall and specific mental disorders due to particulate matter pollution: A time-series study in Chengdu, China[J]. Environmental Research, 2019,170:230-237.
[18]	Analitis A, De' Donato F, Scortichini M, et al. Synergistic effects of ambient temperature and air pollution on health in Europe: results from the PHASE Project[J]. International Journal of Environmental Research and Public Health, 2018,15(9):1856.
[19]	张宇静,赵天良,殷翀之,等.徐州市大气PM2.5与O3作用关系的季节变化[J]. 中国环境科学, 2019,39(6):2267-2272. Zhang Y J, Zhao T L, Yin C Z, et al. Seasonal variation of the relationship between surface PM2.5 and O3 concentrations in Xuzhou[J]. China Environmental Science, 2019,39(6):2267-2272.
[20]	Murray C J, Lopez A D. Measuring the global burden of disease[J]. The New England Journal of Medicine, 2013,369(5):448-457.
[21]	Lu F, Zhou L, Xu Y, et al. Short-term effects of air pollution on daily mortality and years of life lost in Nanjing, China[J]. Science of the Total Environment, 2015,536:123-129.
[22]	Ma Y, Pei S, Shaman J, et al. Role of meteorological factors in the transmission of SARS-CoV-2 in the United States[J]. Nature Communications, 2021,12(1):3602.
[23]	Silva R A, Adelman Z, Fry M M, et al. The Impact of Individual Anthropogenic Emissions Sectors on the Global Burden of Human Mortality due to Ambient Air Pollution[J]. Environmental Health Perspectives, 2016,124(11):1776-1784.
[24]	Wang N, Mengersen K, Tong S, et al. Short-term association between ambient air pollution and lung cancer mortality[J]. Environmental Research, 2019,179(Pt A):108748.
[25]	Anwar A, Ayub M, Khan N, et al. Nexus Between air pollution and neonatal deaths: A case of Asian countries[J]. International Journal of Environmental Research and Public Health, 2019,16(21):4148.
[26]	Moreno-Macías H, Dockery D W, Schwartz J, et al. Ozone exposure, vitamin C intake, and genetic susceptibility of asthmatic children in Mexico City: a cohort study[J]. Respiratory Research, 2013,14(1):14.
[27]	Yang C, Yang H, Guo S, et al. Alternative ozone metrics and daily mortality in Suzhou: the China Air Pollution and Health Effects Study (CAPES)[J]. Science of the Total Environment, 2012,426:83-89.
[28]	Dehghan A, Khanjani N, Bahrampour A, et al. The relation between air pollution and respiratory deaths in Tehran, Iran- using generalized additive models[J]. BMC Pulmonary Medicine, 2018,18(1):49.
[29]	付桂琴,田亚芹,张成伟.气温与臭氧协同作用对COPD住院人数的影响[J]. 中国环境科学, 2019,39(12):5312-5318. Fu G Q, Tian Y Q, Zhang C W. Synergistic effect of temperature and O3 on the numbers of COPD hospitalizations[J]. China Environmental Science, 2019,39(12):5312-5318.
[30]	Silva A V, Oliveira C M, Canha N, et al. Long-term assessment of air quality and identification of aerosol sources at Setúbal, Portugal[J]. International Journal of Environmental Research and Public Health, 2020,17(15):5447.
[31]	Gordon C J. Role of environmental stress in the physiological response to chemical toxicants[J]. Environmental Research, 2003,92(1):1-7.
[32]	Markandya A, Chiabai A. Valuing climate change impacts on human health: empirical evidence from the literature[J]. International Journal of Environmental Research and Public Health, 2009,6(2):759-786.
[33]	Mabula J B, Chalya P L, Mchembe M D, et al. Skin cancers among Albinos at a University teaching hospital in Northwestern Tanzania: a retrospective review of 64 cases[J]. BMC Dermatology, 2012,12:5.
[34]	Wu S, Deng F, Hao Y, et al. Fine particulate matter, temperature, and lung function in healthy adults: findings from the HVNR study[J]. Chemosphere, 2014,108:168-174.
[35]	Sun S, Cao P, Chan K P, et al. Temperature as a modifier of the effects of fine particulate matter on acute mortality in Hong Kong[J]. Environmental Pollution, 2015,205:357-364.
[36]	Li C, Dai Z, Yang L, et al. Spatiotemporal Characteristics of Air Quality across Weifang from 2014-2018[J]. International Journal of Environmental Research and Public Health, 2019,16(17):3122.
[37]	Li S, Guo Y, Williams G, et al. The association between ambient temperature and children's lung function in Baotou, China[J]. International Journal of Biometeorology, 2015,59(7):791-798.
[38]	Shi W, Liu C, Annesi-Maesano I, et al. Ambient PM2.5 and its chemical constituents on lifetime-ever pneumonia in Chinese children: A multi- center study[J]. Environment International, 2021,146: 106176.
[39]	Yang H, Peng Q, Zhou J, et al. The unidirectional causality influence of factors on PM2.5 in Shenyang city of China[J]. Scientific Reports, 2020,10(1):8403.
[40]	Oh J, Lee S, Kim M H, et al. The impact of PM2.5 on acute otitis media in children (aged 0-3): A time series study[J]. Environmental International, 2020,145:106133.
[41]	Luo B, Shi H, Wang L, et al. Rat lung response to PM2.5 exposure under different cold stresses[J]. International Journal of Environmental Research and Public Health, 2014,11(12):12915-12926.
[42]	罗斌,晚亚雄,石艳荣,等.低温刺激与PM2.5对大鼠肺组织及系统炎症因子的影响[J]. 科学技术与工程, 2015,15(7):30-33. Luo B, Wan Y X, Shi Y R, et al. Effect of cold stimulation and PM2.5on inflammatory factors in rat lung tissue system[J]. Science Technology and Engineering, 2015,15(7):30-33.
[43]	罗斌,刘江涛,费高强,等.不同温度刺激与大气PM2.5对大鼠肺泡巨噬细胞的交互毒性作用研究[J]. 中国应用生理学杂志, 2017, 33(1):71-75. Luo B, Liu J T, Fei G Q, et al. Interactive toxicity of different temperature stimulation and atmospheric PM2.5 on rat alveolar macrophages[J]. Chinese Journal of Applred Physiology, 2017,33(1): 71-75.
[44]	Li Y, Zhou J, Rui X, et al. PM2.5 exposure exacerbates allergic rhinitis in mice by increasing DNA methylation in the IFN-γ gene promoter in CD4+T cells via the ERK-DNMT pathway[J]. Toxicology Letters, 2019,301:98-107.
[45]	Sun L, Fu J, Lin S H, et al. Particulate matter of 2.5μm or less in diameter disturbs the balance of TH17/regulatory T cells by targeting glutamate oxaloacetate transaminase 1and hypoxia-inducible factor 1α in an asthma model[J]. Journal of Allergy and Clinical Immunology, 2020,145(1):402-414.
[46]	Zhou J, Geng F, Xu J, et al. PM2.5 exposure and cold stress exacerbates asthma in mice by increasing histone acetylation in IL-4gene promoter in CD4+ T cells[J]. Toxicology Letters, 2019,316:147-153.
[47]	Zhou J, Xu J, Geng F, et al. Childhood co-exposure of cold stress and PM2.5 aggravates the susceptibility and severity of asthma in adulthood of mice[J]. Environmental Toxicology, 2021,36(2):177-184.
[48]	付世华,周骥,叶晓芳,等.低温联合PM2.5对小鼠哮喘气道炎症的影响[J]. 中国环境科学, 2021,41(7):3343-3348. Fu S H, Zhou J, Ye X F, et al. Effect of hypothermia combined with PM2.5 on airway inflammation in asthmatic mice[J]. China Environmental Science, 2021,41(7):3343-3348.