1. Instrumentation and Service Center for Science and Technology, Beijing Normal University, Zhuhai 519087, China; 2. Key Laboratory of Water and Sediment Sciences of Ministry of Education, School of Environment, Beijing Normal University, Beijing 100875, China; 3. Advanced Interdisciplinary Institute of Environment and Ecology, Beijing Normal University, Zhuhai 519087, China; 4. College of Environment Science and Engineering, Central South University of Forestry and Technology, Changsha 410004, China
Abstract：Perfluoroalkyl acids (PFAAs) are a class of ubiquitous organic pollutants in aquatic environment. The PFAAs can be accumulated in various organisms, and thus induce diverse toxic effects. By studying the bioconcentration of short-chain PFAAs in Daphnia magna under exposure conditions with and without long-chain PFAAs, we herein analyzed the uptake rate constant (ku), elimination rate constant (ke), and bioconcentration factors at steady state (BCFss) of PFAAs in Daphnia magna, and subsequently attempted to uncover mechanisms underpinning the influence of long-chain PFAAs on shorter chain PFAA bioaccumulation. It revealed positive linear associations between ku or BCFss and the numbers of perfluorinated carbon, membrane-water distribution coefficients, protein-water distribution coefficients, and PFAA-protein association constants. Moreover, longer chain PFAAs inhibited the bioconcentration of shorter chain PFAAs, reducing the BCFss to 56%~80%. Such a reduction would be caused by competitive binding to proteins between longer and shorter chain PFAAs.
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