Uptake, distribution and biotransformation of 8:2 fluorotelomer carboxylic acid (8: 2FTCA) in scallops (Patinopecten yessoensis)
GUO Meng-meng1, GUO Jiao2, LI Feng-ling1, WANG Zhi3, LIU Xiao-yu1, ZHAI Yu-xiu1, TAN Zhi-jun1
1. Key Laboratory of Testing and Evaluation for Aquatic Product Safety and Quality, Ministry of Agriculture and Rural Affairs, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao 266071, China; 2. Burning Rock Biotech, Guangzhou 510300, China; 3. Qingdao Institute of Product Quality Inspection and Technical Research, Qingdao Product Quality Supervision and Testing Resarch, Qingdao 266101, China
Abstract：The uptake, tissue distribution and biotransformation of 8:2fluorotelomer carboxylic acid (8:2FTCA) in liver, gills, sexual gland, mantle and adductor muscle tissues of the scallop Patinopecten yessoensis were investigated. The highest concentration of 8:2 FTCA was detected in the liver, and the maximum uptake rate of 8:2 FTCA in the gills. Five metabolic products, including 8:2 fluorotelomer unsaturated carboxylic acid (8:2 FTUCA), 7:3 fluorotelomer carboxylic acid (7:3 FTCA), perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA) and perfluoroheptanoic acid (PFHpA) were identified in scallops. 7:3 FTCA and PFOA were major metabolites, which tended to accumulate in gills and liver. The biotransformation of parent compound 8:2 FTCA was dominantly occurred in gills, where the metabolites were present at the highest concentrations. The biotransformation pathway of 8:2 FTCA in P. yessoensis was proposed for the first time. Compared with the biotransformation behavior of 8:2 FTCA in rainbow trout, the distinct species differences were observed in the yield and half-life of metabolites in P. yessoensis. These results indicated that 8:2 FTCA can be easily transformed in P. yessoensis, and the detection of PFOA, PFNA and PFHpA indicates that exposure to 8:2 FTCA may be an indirect route of exposure to PFCAs in scallops.
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