Tissue distribution, accumulation, elimination characteristics and toxicity of 2,2’,4,4’-tetrabromodiphenyl ether in blue mussel
GENG Qian-qian1, GUO Meng-meng1, LI Feng-ling1, LIU Xiao-yu1,2, WU Feng1,3, YU Xin4, ZHAI Yu-xiu1, TAN Zhi-jun1,5,6
1. Key Laboratory of Testing and Evaluation for Aquatic Product Safety and Quality, Ministry of Agriculture and Rural Affairs, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao 266071, China; 2. College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China; 3. College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266061, China; 4. College of Plant Medicine, Qingdao Agricultural University, Qingdao 266109, China; 5. Pilot National Laboratory for Marine Science and Technology (Qingdao), Qingdao 266071, China; 6. Collaborative Innovation Center of Seafood Deep Processing, Dalian Polytechnic University, Dalian 116034, China
Abstract：The distribution, bioaccumulation and elimination dynamics of 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) in mussel (Mytilus galloprovincialis) tissues were studied, and the toxic effects of BDE-47 on mussel were investigated. Results showed that blue mussel had strong bioaccumulation ability and certain elimination ability to BDE-47, and the accumulation was tissue-specific and concentration-dependent. Digestive gland and gill were the target organs where BDE-47 accumulated. The content of BDE-47 in tissues at accumulation or elimination stage accorded with the first-order nonlinear accumulation/attenuation model. The elimination half-life and bioconcentration factors (BCFs) of BDE-47 in mussel tissues were 0.68~7.62d and 3217~140970L/Kg under 0.01~1μg/L exposure solution, respectively. BDE-47exposure induced antioxidant defence system and tissue damages in both digestive gland and gill. Superoxide dismutase (SOD) activity, malondialdehyde (MDA) content and glutathione-S-transferase (GST) activity can be used as candidate biomarkers of BDE-47exposure.
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