中国典型湖泊四大类抗生素污染特征

张晶晶; 陈娟; 王沛芳; 王超; 高寒; 胡煜

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中国环境科学 ›› 2021, Vol. 41 ›› Issue (9) : 4271-4283.

环境生态

中国典型湖泊四大类抗生素污染特征

张晶晶^1,2, 陈娟^1,2, 王沛芳^1,2, 王超^1,2, 高寒^1,2, 胡煜^1,2

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Pollution characteristics of four-type antibiotics in typical lakes in China

ZHANG Jing-jing^1,2, CHEN Juan^1,2, WANG Pei-fang^1,2, WANG Chao^1,2, GAO Han^1,2, HU Yu^1,2

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摘要

基于已有文献资料数据，以中国东部平原湖区（31个），蒙新湖区（4个），二龙湖，青海湖及抚仙湖共38个典型湖泊为研究对象，总结分析四大类常用抗生素（四环素类，磺胺类，喹诺酮类和大环内酯类）在湖泊水体和沉积物中的污染特征.结果表明，四大类抗生素污染在中国典型湖泊中普遍存在，其中水体中抗生素污染水平依次为磺胺类（2147ng/L） > 喹诺酮类（1458ng/L） > 四环素类（481ng/L） > 大环内酯类（205ng/L），沉积物中抗生素的分布具有垂向差异特征，表层沉积物抗生素浓度高于深层沉积物.抗生素检出浓度在不同湖区间存在较大差异，其中东部平原湖区水体和沉积物中抗生素浓度显著高于其他湖区.相比入湖河流，湖区（如太湖贡湖湾和青海湖）水体中抗生素污染相对较高，表明湖区可能作为抗生素的汇集地.湖泊水体中的抗生素浓度分布呈现季节性差异，如太湖水体中抗生素浓度在春，夏及冬季高于秋季，而鄱阳湖，白洋淀和二龙湖在旱季（4月）高于雨季（8月）；而湖泊沉积物中抗生素季节性差异较不明显，这可能与抗生素在沉积物中的迁移性有关.

Abstract

Based on existing literature data, we analyzed the pollution characteristics of four-type antibiotics used commonly, including tetracyclines, sulfonamides, quinolones and macrolides, in 38 typical lakes, which are distributed in eastern plain lake region (31), Mengxin lake district (4), Erlong Lake, Qinghai Lake and Fuxian Lake. The results showed that the four-type antibiotics were ubiquitous in waterbody and sediments of these lakes, and the pollution concentrations decreased as follows:SAs (2147ng/L)> quinolones (QNs, 1458ng/L)> tetracyclines (TCs, 481 ng/L)> macrolides (MLs, 205 ng/L). The antibiotics in sediments exhibited vertical difference, with higher pollution concentration in surface sediment than that in deep sediments. The antibiotics concentrations varied among different lake regions, and in the eastern plain lake region showed higher contamination level. Compared with the inflow rivers, lakes, such as the Gonghu Bay in Taihu Lake and Qinghai Lake, generally showed relatively higher contamination levels, suggesting that lakes serve as a reservoir of antibiotics. Seasonal comparison in pollution levels in waterbody of lakes showed that the antibiotic concentrations in pring, summer and winter was significantly higher than that in the autumn. For example, Poyang Lake, Baiyangdian Lake and Erlong Lake' antibiotic pollution was higher in dry season (April) than in rainy season (August). However, antibiotics concentrations in lake sediments were comparable between different seasons, probably resulting from the migration of antibiotics in sediments.

导出引用

张晶晶, 陈娟, 王沛芳, 王超, 高寒, 胡煜. 中国典型湖泊四大类抗生素污染特征[J]. 中国环境科学. 2021, 41(9): 4271-4283

ZHANG Jing-jing, CHEN Juan, WANG Pei-fang, WANG Chao, GAO Han, HU Yu. Pollution characteristics of four-type antibiotics in typical lakes in China[J]. China Environmental Science. 2021, 41(9): 4271-4283

中图分类号： X524

参考文献

[1] Andersson D I, Hughes D. Microbiological effects of sublethal levels of antibiotics[J]. Nature Reviews Microbiology, 2014,12(7):465-478.
[2] Ben Y J, Fu C X, Hu M, et al. Human health risk assessment of antibiotic resistance associated with antibiotic residues in the environment:A review[J]. Environmental Research, 2019,169(2):483-493.
[3] Zhang Q Q, Ying G G, Pan C G, et al. Comprehensive evaluation of antibiotics emission and fate in the river basins of China:Source analysis, multimedia modeling, and linkage to bacterial resistance[J]. Environmental science & Technology, 2015,49(11):6772-6782.
[4] 孙金昭.城市生活垃圾填埋场中抗生素残留浓度征及抗性基因相关性研究[D]. 上海:华东师范大学, 2017.Sun J Z. Characteristics of antibiotics contents in municipal solid waste landfills and correlation with antibiotic resistance genes[D]. Shanghai:East China Normal University, 2017.
[5] Wang J L, Zhuan R, Chu L B. The occurrence, distribution and degradation of antibiotics by ionizing radiation:An overview[J]. Science of the Total Environment, 2019,646(1):1385-1397.
[6] Hartmann A, Alder A C, Koller T, et al. Identification of fluoroquinolone antibiotics as the main source of umuC genotoxicity in native hospital wastewater[J]. Environmental Toxicology & Chemistry, 2010,17(3):377-382.
[7] 徐艳,张远,郭昌胜,等.石家庄汪洋沟地区抗生素,抗性细菌和抗性基因污染特征[J]. 农业环境科学学报, 2014,33(6):1174-1182.Xu Y, Zhang Y, Guo C S, et al. Pollution characteristics of antibiotics and antibiotic-resistant bacteria and genes in Wangyanggou River, Shijiazhuang, China[J]. Journal of Agro-Environment Science, 2014, 33(6):1174-1182.
[8] Jacobsen P L, Berglind L. Persistence of oxytetracycline in sediments from fish farms[J]. Aquaculture, 1988,70(4):365-370.
[9] Samuelsen O B. Degradation of oxytetracycline in seawater at two different temperatures and light intensities, and the persistence of oxytetracycline in the sediment from a fish farm[J]. Aquaculture, 1989,83(1/2):7-16.
[10] 刘洁.三峡库区典型支流沉积物中抗生素及抗性基因多样性研究[D]. 重庆:重庆大学, 2019.Liu J. Study on diversity of antibiotics and resistance genes in typical tributary sediments from the Three Gorges Reservoir[D]. Chongqing:Chongqing University, 2019.
[11] Murata A, Takada H, Mutoh K, et al. Nationwide monitoring of selected antibiotics:Distribution and sources of sulfonamides, trimethoprim, and macrolides in Japanese rivers[J]. Science of the Total Environment, 2011,409(24):5305-5312.
[12] Xu W H, Yan W, Li X D, et al. Antibiotics in riverine runoff of the Pearl River Delta and Pearl River Estuary, China:Concentrations, mass loading and ecological risks[J]. Environmental Pollution, 2013, 182(6):402-407.
[13] Xu W H, Zhang G, Zou S C, et al. A preliminary investigation on the occurrence and distribution of antibiotics in the Yellow River and its tributaries, China[J]. Water Environment Research, 2009,81(3):248.
[14] Xu J, Zhang Y, Zhou C B, et al. Distribution, sources and composition of antibiotics in sediment, overlying water and pore water from Taihu Lake, China[J]. Science of the Total Environment, 2014,497-498:267-273.
[15] Tang J, Shi T Z, Wu X W, et al. The occurrence and distribution of antibiotics in Lake Chaohu, China:Seasonal variation, potential source and risk assessment[J]. Chemosphere, 2015,122:154-161.
[16] Zhang R J, Zhang G, Zheng Q, et al. Occurrence and risks of antibiotics in the Laizhou Bay, China:Impacts of river discharge[J]. Ecotoxicology and Environmental Safety, 2012,80(2):208-215.
[17] Zhang R J, Tang J H, Li J, et al. Antibiotics in the offshore waters of the Bohai Sea and the Yellow Sea in China:Occurrence, distribution and ecological risks[J]. Environmental Pollution, 2013,174(3):71-77.
[18] Yang J F, Ying G G, Zhao J L, et al. Spatial and seasonal distribution of selected antibiotics in surface waters of the Pearl Rivers, China[J]. Journal of Environmental Science & Health Part B, 2011,46(3):272-280.
[19] Luo Y, Xu L, Rysz M, et al. Occurrence and transport of tetracycline, sulfonamide, quinolone, and macrolide antibiotics in the Haihe River Basin, China[J]. Environmental Science & Technology, 2011,45(5):1827-1833.
[20] Xu Z A, Li T, Bi J, et al. Spatiotemporal heterogeneity of antibiotic pollution and ecological risk assessment in Taihu Lake Basin, China[J]. Science of the Total Environment, 2018,643:12-20.
[21] Yang J F, Ying G G, Zhao J L, et al. Simultaneous determination of four classes of antibiotics in sediments of the Pearl Rivers using RRLC-MS/MS[J]. Science of the Total Environment, 2010,408(16):3424-3432.
[22] Kim K R, Owens G, Kwon S I, et al. Occurrence and environmental fate of veterinary antibiotics in the terrestrial environment[J]. Water Air and Soil Pollution, 2011,214(1-4):163-174.
[23] Li L, Liu D, Zhang Q, et al. Occurrence and ecological risk assessment of selected antibiotics in the freshwater lakes along the middle and lower reaches of Yangtze River Basin[J]. Journal of Environmental Management, 2019,249:109396.
[24] Yan Z H, Yang H H, Dong H K, et al. Occurrence and ecological risk assessment of organic micropollutants in the lower reaches of the Yangtze River, China:A case study of water diversion[J]. Environmental Pollution, 2018,239:223-232.
[25] Qin Y W, Wen Q, Ma Y Q, et al. Antibiotics pollution in Gonghu Bay in the period of water diversion from Yangtze River to Taihu Lake[J]. Environmental Earth Sciences, 2018,77(11):419.1-419.11.
[26] Wang W X, Zhou L J, Gu X H, et al. Occurrence and distribution of antibiotics in surface water impacted by crab culturing:A case study of Lake Guchenghu, China[J]. Environmental Science and Pollution Research, 2018,25(23):22619-22628.
[27] 唐俊,陈海燕,史陶中,等.巢湖喹诺酮及四环素类药物污染现状及来源分析[J]. 安徽农业大学学报, 2013,40(6):1043-1048.Tang J, Chen H Y, Shi T Z, et al. Occurrence of quinolones and tetracyclines antibiotics in the aquatic environment of Chaohu Lake[J]. Journal of Anhui Agricultural University, 2013,40(6):1043-1048.
[28] Han M Z, Dsouza M, Zhou C Y, et al. Agricultural risk factors influence microbial ecology in Honghu Lake[J]. Genomics Proteomics & Bioinformatics, 2019,17(1):76-90.
[29] Wang Y Q, Liu Y, Lu S Y, et al. Occurrence and ecological risk of pharmaceutical and personal care products in surface water of the Dongting Lake, China-during rainstorm period[J]. Environmental Science and Pollution Research, 2019,26(28):28796-28807.
[30] Zhou L J, Li J, Zhang Y, et al. Trends in the occurrence and risk assessment of antibiotics in shallow lakes in the lower-middle reaches of the Yangtze River basin, China[J]. Ecotoxicology and Environmental Safety, 2019,183:109511.
[31] 刘晓晖,卢少勇.大通湖表层水体中抗生素赋存特征与风险[J]. 中国环境科学, 2018,38(1):320-329.Liu X H, Lu S Y. Occurrence and ecological risk of typical antibiotics in surface water of the Datong Lake, China[J]. China Environmental Science, 2018,38(1):320-329.
[32] Ding H J, Wu Y X, Zhang W H, et al. Occurrence, distribution, and risk assessment of antibiotics in the surface water of Poyang Lake, the largest freshwater lake in China[J]. Chemosphere, 2017,184:137-147.
[33] Zhang L L, Shen L N, Qin S, et al. Quinolones antibiotics in the Baiyangdian Lake, China:Occurrence, distribution, predicted no-effect concentrations (PNECs) and ecological risks by three methods[J]. Environmental Pollution, 2020,256(1):113458.1-113458.9.
[34] Zhang P W, Zhou H D, Li K, et al. Occurrence of pharmaceuticals and personal care products, and their associated environmental risks in a large shallow lake in North China[J]. Environmental Geochemistry and Health, 2018,40(4):1525-1539.
[35] Cheng D M, Liu X H, Wang L, et al. Seasonal variation and sediment-water exchange of antibiotics in a shallower large lake in North China[J]. Science of the Total Environment, 2014,476:266-275.
[36] Li W H, Shi Y L, Gao L H, et al. Occurrence of antibiotics in water, sediments, aquatic plants, and animals from Baiyangdian Lake in North China[J]. Chemosphere, 2012,89(11):1307-1315.
[37] Zhang G D, Liu X H, Lu S Y, et al. Occurrence of typical antibiotics in Nansi Lake's inflowing rivers and antibiotic source contribution to Nansi Lake based on principal component analysis-multiple linear regression model[J]. Chemosphere, 2020,242(12):52-69.
[38] 杨宇轩.骆马湖表层水典型抗生素赋存特征及沉积物吸附行为研究[D]. 徐州:中国矿业大学, 2020.Yang Y X. Occurrence characteristics of typical antibiotics in surface water of Luoma Lake and adsorption behavior on sediments[D]. Xuzhou:China University of Mining and Technology, 2020.
[39] 王瑞杰,裘钱玲琳,李国祥,等.宁波月湖水体中抗生素分布与生态风险评价[J]. 湖泊科学, 2018,30(6):1616-1624.Wang R J, QiuQian L L, Li G X, et al. Distribution characteristics and ecological risk assessment of selected antibiotics in Moon Lake, Ningbo City[J]. Journal of Lake Sciences, 2018,30(6):1616-1624.
[40] 肖鑫鑫,吴亦潇,丁惠君,等.武汉城市湖泊抗生素及抗性基因的污染特征研究[J]. 环境科学与技术, 2019,42(3):9-16.Xiao X X, Wu Y X, Ding H J, et al. Pollution characteristics of antibiotics and antibiotic resistance genesin urban lakes of Wuhan[J]. Environmental Science & Technology, 2019,42(3):9-16.
[41] 雷晓宁.新疆典型湖泊中抗生素的污染状况与分布特征[D]. 石河子:石河子大学, 2014.Lei X N. Distribution and pollution levels of antibiotics from typical lakes in Xinjiang[D]. Shihezi:Shihezi University, 2014.
[42] Lei X N, Lu J J, Liu Z L, et al. Concentration and distribution of antibiotics in water-sediment system of Bosten Lake, Xinjiang[J]. Environmental Science and Pollution Research, 2015,22(3):1670-1678.
[43] 王倩倩.新疆阿拉山口及周边水环境中多种抗生素的污染水平研究[D]. 石河子:石河子大学, 2016.Wang Q Q. Pollution levels of antibiotics from aquatic environment in Alashankou Region of Xinjiang and surrounding area[D]. Shihezi:Shihezi University, 2016.
[44] Zhao B, Xu J M, Zhang G D, et al. Occurrence of antibiotics and antibiotic resistance genes in the Fuxian Lake and antibiotic source analysis based on principal component analysis-multiple linear regression model[J]. Chemosphere, 2020,262:127741.
[45] Li S, Kuang Y Z, Hu J R, et al. Enrichment of antibiotics in an inland lake water[J]. Environmental Research, 2020,190:110029.
[46] Li S J, Ju H Y, Zhang J Q, et al. Occurrence and distribution of selected antibiotics in the surface waters and ecological risk assessment based on the theory of natural disaster[J]. Environmental Science and Pollution Research, 2019,26(27):28384-28400.
[47] 王娜.环境中磺胺类抗生素及其抗性基因的污染特征及风险研究[D]. 南京:南京大学, 2014.Wang N. Pollution characteristics and risk of sulfonamides antibiotics and their resistance genes in the environment[D]. Nanjing:Nanjing University, 2014.
[48] Li S J, Ju H Y, et al. Terrestrial humic-like fluorescence peak of chromophoric dissolved organic matter as a new potential indicator tracing the antibiotics in typical polluted watershed[J]. Journal of Environmental Management, 2018,228(12.15):65-76.
[49] Zhang G D, Lu S Y, Wang Y Q, et al. Occurrence of antibiotics and antibiotic resistance genes and their correlations in lower Yangtze River, China[J]. Environmental Pollution, 2020,257:113365.
[50] Böger B, Surek M, Vilhena R d O, et al. Occurrence of antibiotics and antibiotic resistant bacteria in subtropical urban rivers in Brazil[J]. Journal of Hazardous Materials, 2021,402:123448.
[51] Ngumba E, Gachanja A, Tuhkanen T. Occurrence of selected antibiotics and antiretroviral drugs in Nairobi River Basin, Kenya[J]. Science of the Total Environment, 2016,539:206-213.
[52] 廖杰,魏晓琴,肖燕琴,等.莲花水库水体中抗生素污染特征及生态风险评价[J]. 环境科学, 2020,41(9):205-211.Liao J, Wei X Q, Xiao Y Q, et al. Pollution characteristics and risk assessment of antibiotics in Lianhua Reservoir[J]. Environmental Science, 2020,41(9):205-211.
[53] 董莞莞,何欣,郑洪波,等.大连碧流河水库及河流典型抗生素污染和分布特征研究[J]. 大连理工大学学报, 2020,60(2):119-127.Dong W W, He X, Zhen H B, et al. Research on occurrences and distribution characteristics of typical antibiotics in Biliuhe Reservoir and its inflow rivers in Dalian[J]. Journal of Dalian University of Technology, 2020,60(2):119-127.
[54] Liu X H, Lu S Y, Guo W, et al. Antibiotics in the aquatic environments:A review of lakes, China[J]. Science of the Total Environment, 2018, 627:1195-1208.
[55] Lei K, Zhu Y, Chen W, et al. Spatial and seasonal variations of antibiotics in river waters in the Haihe River Catchment in China and ecotoxicological risk assessment[J]. Environment International, 2019, 130:104919.
[56] Wang Z, Han M Z, Li E H, et al. Distribution of antibiotic resistance genes in an agriculturally disturbed lake in China:Their links with microbial communities, antibiotics, and water quality[J]. Journal of Hazardous Materials, 2020,393:122426.
[57] Sarmah A K, Meyer M T, Boxall A B A. A global perspective on the use, sales, exposure pathways, occurrence, fate and effects of veterinary antibiotics (VAs) in the environment[J]. Chemosphere, 2006,65(5):725-759.
[58] 安清聪,张曦,陈克嶙.动物组织中四环素类抗生素残留的ELISA检测研究-土霉素抗体的制备[J]. 畜牧与兽医, 2004,36(9):8-10.An Q C, Zhang X, Chen K L. Detection of tetracyclines residue in animal tissues by ELISA:Preparation of anti-OTC antibodies[J]. Animal Husbandry & Veterinary Medicine, 2004,36(9):8-10.
[59] 武旭跃,邹华,朱荣,等.太湖贡湖湾水域抗生素污染特征分析与生态风险评价[J]. 环境科学, 2016,37(12):4596-4604.Wu Y H, Zou H, Zhu R, et al. Occurrence, distribution and ecological risk of antibiotics in surface water of the Gonghu Bay, Taihu Lake[J]. Environmental Science, 2016,37(12):4596-4604.
[60] Zou S C, Xu W H, et al. Occurrence and distribution of antibiotics in coastal water of the Bohai Bay, China:Impacts of river discharge and aquaculture activities[J]. Environmental Pollution, 2011,159(10):2913-2920.
[61] Jiang L, Hu X L, Yin D Q, et al. Occurrence, distribution and seasonal variation of antibiotics in the Huangpu River, Shanghai, China[J]. Chemosphere, 2011,82(6):822-828.
[62] 罗方园,潘根兴,李恋卿,等.洪泽湖沉积物中四环素土霉素及相关抗性基因的分布特征及潜在风险分析[J]. 农业环境科学学报, 2017, 36(2):369-375.Luo F Y, Pan G X, Li L Q, et al. The distribution characteristics and potential risk of tetracycline, oxytetracycline and their corresponding genes pollution in sediment ofHongze Lake[J]. Journal of Agro-Environment Science, 2017,36(2):369-375.
[63] Yan C X, Yang Y, Zhou J L, et al. Antibiotics in the surface water of the Yangtze Estuary:Occurrence, distribution and risk assessment[J]. Environmental Pollution, 2013,175(4):22-29.
[64] Chen K, Zhou J L. Occurrence and behavior of antibiotics in water and sediments from the Huangpu River, Shanghai, China[J]. Chemosphere, 2014,95(6):604-612.
[65] Tong L, Qin L T, Guan C, et al. Antibiotic resistance gene profiling in response to antibiotic usage and environmental factors in the surface water and groundwater of Honghu Lake, China[J]. Environmental Science and Pollution Research, 2020,27(25):31995-32005.
[66] Yang Y Y, Xu C, Cao X H, et al. Antibiotic resistance genes in surface water of eutrophic urban lakes are related to heavy metals, antibiotics, lake morphology and anthropic impact[J]. Ecotoxicology, 2017, 26(6):831-840.
[67] Hamad B. The antibiotics market[J]. Nature Reviews Drug Discovery, 2010,9(9):675-676.
[68] Units T. Use of quinolones in food animals and potential impact on human health[A]. 1998.
[69] Sukul P, Spiteller M. Fluoroquinolone antibiotics in the environment[J]. Reviews of Environmental Contamination and Toxicology, 2007, 191:131-162.
[70] Zuccato E, Castiglioni S, Bagnati R, et al. Source, occurrence and fate of antibiotics in the Italian aquatic environment[J]. Journal of Hazardous Materials, 2010,179(1-3):1042-1048.
[71] Yue J, Cong X, Wang X Y, et al. Occurrence, seasonal variation and risk assessment of antibiotics in Qingcaosha Reservoir[J]. Water, 2018,10(2):115.
[72] Choi K, Kim Y, Park J, et al. Seasonal variations of several pharmaceutical residues in surface water and sewage treatment plants of Han River, Korea[J]. Science of the Total Environment, 2008, 405(1-3):120-128.
[73] Zhou L J, Ying G G, Zhao J L, et al. Trends in the occurrence of human and veterinary antibiotics in the sediments of the Yellow River, Hai River and Liao River in northern China[J]. Environmental Pollution, 2011,159(7):1877-1885.
[74] Wang W H, Wang H, Zhang W F, et al. Occurrence, distribution, and risk assessment of antibiotics in the Songhua River in China[J]. Environmental Science and Pollution Research, 2017,24(23):1-11.
[75] Chang X, Meyer M T, Liu X, et al. Determination of antibiotics in sewage from hospitals, nursery and slaughter house, wastewater treatment plant and source water in Chongqing region of Three Gorges Reservoir in China[J]. Environmental Pollution, 2010,158(5):1444-1450.
[76] Figueroa R A, Leonard A, Mackay A A. Modeling tetracycline antibiotic sorption to clays[J]. Environmental Science & Technology, 2004,38(2):476-483.
[77] Zhang J Q, Dong Y H. Effect of low-molecular-weight organic acids on the adsorption of norfloxacin in typical variable charge soils of China[J]. Journal of Hazardous Materials, 2008,151(2/3):833-839.
[78] 汪仙仙,张洪昌,沈根祥,等.典型磺胺类抗生素在稻田土中的纵向迁移[J]. 环境化学, 2018,37(8):71-79.Wang X X, Zhang H C, Shen G X, et al. Vertical migration of typical sulfonamide antibiotics in paddy soil[J]. Environmental Chemistry, 2018,37(8):71-79.
[79] Xie Z X, Lu G H, Yan Z H, et al. Bioaccumulation and trophic transfer of pharmaceuticals in food webs from a large freshwater lake[J]. Environmental Pollution, 2017,222:356-366.
[80] Ohore O E, Addo F G, Han N N, et al. Profiles of ARGs and their relationships with antibiotics, metals and environmental parameters in vertical sediment layers of three lakes in China[J]. Journal of Environmental Management, 2020,255(2):109583.1-109583.12.
[81] Zhang S H, Pang S, Wang P F, et al. Antibiotic concentration and antibiotic-resistant bacteria in two shallow urban lakes after stormwater event[J]. Environmental Science and Pollution Research, 2016,23(10):9984-9992.
[82] Arikan O A, Rice C, Codling E. Occurrence of antibiotics and hormones in a major agricultural watershed[J]. Desalination, 2008, 226(1-3):121-133.
[83] Liang X M, Chen B W, Nie X P, et al. The distribution and partitioning of common antibiotics in water and sediment of the Pearl River Estuary, South China[J]. Chemosphere, 2013,92(11):1410-1416.
[84] Kerrigan J F, Sandberg K D, Engstrom D R, et al. Sedimentary record of antibiotic accumulation in Minnesota Lakes[J]. Science of the Total Environment, 2018,621:970-979.
[85] Blair B D, Crago J P, Hedman C J, et al. Pharmaceuticals and personal care products found in the Great Lakes above concentrations of environmental concern[J]. Chemosphere, 2013,93(9):2116-2123.
[86] 李超.新疆地区典型污染源抗生素抗性基因的污染分布的研究分析[D]. 石河子:石河子大学, 2016.Li C. Distribution and contamination levels of ARGs from typical pollution sources in Xinjiang[D]. Shihezi:Shihezi University, 2016.
[87] Zhang S H, Gu J, Wang C, et al. Characterization of antibiotics and antibiotic resistance genes on an ecological farm system[J]. Journal of Chemistry, 2015,2015:1-8.
[88] Yan M T, Xu C, Huang Y M, et al. Tetracyclines, sulfonamides and quinolones and their corresponding resistance genes in the Three Gorges Reservoir, China[J]. Science of the Total Environment, 2018, 631-632:840-848.
[89] Leung H W, Minh T B, Murphy M B, et al. Distribution, fate and risk assessment of antibiotics in sewage treatment plants in Hong Kong, South China[J]. Environment International, 2012,42(1):1-9.
[90] Lu L H, Liu J, Li Z, et al. Antibiotic resistance gene abundances associated with heavy metals and antibiotics in the sediments of Changshou Lake in the Three Gorges Reservoir area, China[J]. Ecological Indicators, 2020,113:106275.
[91] Jiang Y H, Li M X, Guo C S, et al. Distribution and ecological risk of antibiotics in a typical effluent-receiving river (Wangyang River) in north China[J]. Chemosphere, 2014,112(10):267-274.
[92] Hu X G, Zhou Q X, Luo Y. Occurrence and source analysis of typical veterinary antibiotics in manure, soil, vegetables and groundwater from organic vegetable bases, northern China[J]. Environmental Pollution, 2010,158(9):2992-2998.
[93] Luo Y, Mao D Q, Rysz M, et al. Trends in antibiotic resistance genes occurrence in the Haihe River, China[J]. Environmental Science & Technology, 2010,44(19):7220-7225.
[94] Zhang L L, Shen L N, Qin S, et al. Quinolones antibiotics in the Baiyangdian Lake, China:Occurrence, distribution, predicted no-effect concentrations (PNECs) and ecological risks by three methods[J]. Environmental Pollution, 2020,256(1):113458.1-113458.9.
[95] Liang X M, Guan F L, Chen B W, et al. Spatial and seasonal variations of antibiotic resistance genes and antibiotics in the surface waters of Poyang Lake in China[J]. Ecotoxicology and Environmental Safety, 2020,196(6):110543.
[96] 钟振兴.磺胺抗生素在湖泊沉积物中的吸附和降解行为研究[D]. 重庆:西南大学, 2012.Zhong Z X. Adsorption and degradation of sulfonamides in lake sediments[D]. Chongqing:Southwest University, 2012.