Abstract：In order to clarify the effect of the combined pollution system of graphene oxide and polycyclic aromatic hydrocarbons (PAHs) with pulmonary surfactant (PS), the mode of action and effect of each component were investigated, and the mechanism of action was analyzed. The results show that PS and its components had solubilization effect on PAHs, the solubilization ability was naphthalene < acenaphthene < benzo (a) anthracene. Graphene oxide had certain adsorption on PAHs and PS, and there was competitive adsorption of PAHs and PS, after entering the lung, PS and its components occupy the adsorption sites of PAHs and are loaded on the graphene oxide surface, PAHs were resolved on the surface of graphene oxide under the solubilization of PS and its components, and the toxicity was enhanced. The resolution effect of DPPC due to competitive adsorption was particularly significant, when the amount of benzo (a) anthracene added was 0.6mg/L, the adsorption capacity of DPPC on GO was reduced by 28.92mg/g. At the same time, both PAHs and PS will promote the agglomeration of graphene oxide and the particle size will increase by more than 3times; the increase in C=C bonds and the effect of chemical bond conversion affect stability of graphene oxide. This study provides some theoretical support for the potential toxic effects of compound pollution on the lung and lung risk assessment.
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