某矿区居民混合金属暴露与早期肾功能损害相关性

摘要
图/表
参考文献
相关文章 (15)

全文: PDF (742 KB) HTML (1 KB)
输出: BibTeX | EndNote (RIS)

摘要为揭示某矿区居民镉、铜、锰、钼、铬、铝、钴、钒、铅、砷、锌、镍12种金属暴露现状,进而分析混合金属暴露与早期肾功能损害指标尿β2-微球蛋白(β2-MG)和N-乙酰-β-D-氨基葡萄糖苷酶(NAG)之间的关联,按照分层整群抽样选取矿区636名居民为研究对象,使用ICP-MS检测研究对象尿金属浓度,分别使用胶乳免疫比浊法和比色法测定研究对象尿β2-MG和NAG水平,然后并使用加权量化和回(WQS回归)模型评估混合金属暴露对尿β2-MG和NAG的综合效应与单个金属的权重.结果显示,尿液金属水平分布差异较大的是镉、钼、铜、铝、锌、钒;尿β2-MG分布范围为0.19(0.14, 0.29)mg/L;尿NAG分布范围在7.00(3.30, 11.90)U/L;WQS回归结果显示金属WQS指数与尿β2-MG异常风险增加、尿NAG异常风险降低有关.使尿β2-MG异常风险增加的金属WQS指数权重最高的是铜(0.493)、铬(0.120)、镉(0.116),不同年龄组中权重相对较高的金属包括钼、锰、锌(<60岁组);铜、镉、钼(≥60岁组).使尿NAG异常风险降低的金属WQS指数权重最高的是锌(0.328)、钼(0.167)、铬(0.144)、镍(0.138)、锰(0.108),不同年龄组中权重相对较高的金属包括铝、钼、锌(<60岁组);钴、铬、钼(≥60岁组).因此,该矿区人群尿镉、钼、铜、铝、锌、钒水平分布在中等偏上范围,暴露于混合金属与尿β2-MG异常风险增加和尿NAG异常风险降低之间存在关联,引起β2-MG异常权重较高金属有铜、铬、镉,减少NAG异常权重较高金属有锌、钼、铬、镍、锰.

	服务

	把本文推荐给朋友
	加入我的书架
	加入引用管理器
	E-mail Alert
	RSS
	作者相关文章
	胡晓斌
	杨轶男
	李巧娥
	马执彬
	白亚娜

关键词 ：混合金属, 早期肾功能损害指标, 相关性, WQS回归

Abstract：In order to reveal the current status of cadmium, copper, manganese, molybdenum, chromium, aluminum, cobalt, vanadium, lead, arsenic, zinc, and nickel exposure in a mining area, and to analyze the association between mixed metal exposure and urinary β2-microglobulin (β2-MG) and N-acetyl-β-D-aminoglucosidase (NAG), which are indicators of early renal impairment, 636residents of the mining area were selected according to stratified whole-group sampling, and urinary β2-MG and NAG levels were measured by ICP-MS. The urinary metal concentrations were measured by ICP-MS, and the urinary β2-MG and NAG levels were determined by latex immunoturbidimetric and colorimetric methods, respectively. The combined effect of mixed metal exposure on urinary β2-MG and NAG was then evaluated using a weighted quantile and regression (WQS regression) model with the weights of individual metals. The results showed that the distribution of urinary metal levels varied widely for cadmium, molybdenum, copper, aluminum, zinc, and vanadium; the distribution of urinary β2-MG ranged from 0.19 (0.14, 0.29) mg/L; the distribution of urinary NAG ranged from 7.00 (3.30, 11.90) U/L; the WQS regression results showed that the metal WQS index was associated with an increased risk of abnormal urinary β2-MG and an abnormal risk of abnormal urinary NAG reduced risk of urinary NAG abnormalities. The metals with the highest WQS index weights that increased the risk of urinary β2-MG abnormalities were copper 0.493, chromium 0.120, and cadmium 0.116. The metals with relatively high weights in different age groups included molybdenum, manganese, and zinc (<60years old group); and copper, cadmium, and molybdenum (≥60years old group). The metals with the highest WQS index weights to reduce the risk of urinary NAG abnormalities were zinc 0.328, molybdenum 0.167, chromium 0.144, nickel 0.138, and manganese 0.108. The metals with relatively high weights in different age groups included aluminum, molybdenum, and zinc (<60years group); and cobalt, chromium, and molybdenum (≥60years group). Therefore, the distribution of urinary cadmium, molybdenum, copper, aluminum, zinc, and vanadium levels in this mining population was in the middle to upper range. There was an association between exposure to mixed metals and increased risk of urinary β2-MG abnormalities and decreased risk of urinary NAG abnormalities. The metals causing higher weights of β2-MG abnormalities were copper, chromium, and cadmium, and the metals reducing higher weights of NAG abnormalities were zinc, molybdenum, chromium, nickel, and manganese.

Key words： mixed metals indicators of early renal function impairment correlation Weighted Quantile Sum Regression

收稿日期: 2023-09-07

PACS:	X18
	R18

基金资助:甘肃省自然科学基金(20JR10RA599)

通讯作者: 白亚娜,教授,baiyana@lzu.edu.cn E-mail: baiyana@lzu.edu.cn

引用本文:

胡晓斌, 杨轶男, 李巧娥, 马执彬, 白亚娜. 某矿区居民混合金属暴露与早期肾功能损害相关性[J]. 中国环境科学, 2024, 44(4): 2357-2368. HU Xiao-bin, YANG Yi-Nan, LI Qiao-e, MA Zhi-Bin, BAI Ya-Na. Correlation analysis of mixed metal exposure and early renal function impairment indicators in a mining area. CHINA ENVIRONMENTAL SCIENCECE, 2024, 44(4): 2357-2368.

链接本文:

http://www.zghjkx.com.cn/CN/ 或 http://www.zghjkx.com.cn/CN/Y2024/V44/I4/2357

[1] Ohsawa M. Biomarkers for responses to heavy metals[J]. Cancer Causes & Control:CCC, 1997,8(3):514-517.
[2] Diamond G L, Zalups R K. Understanding renal toxicity of heavy metals[J]. Toxicologic Pathology, 1998,26(1):92-103.
[3] Rani A, Kumar A, Lal A, et al. Cellular mechanisms of cadmium-induced toxicity:a review[J]. International Journal of Environmental Health Research, 2014,24(4):378-399.
[4] Prozialeck W C, Edwards J R. Mechanisms of cadmium-induced proximal tubule injury:new insights with implications for biomonitoring and therapeutic interventions[J]. The Journal of Pharmacology and Experimental Therapeutics, 2012,343(1):2-12.
[5] Patlolla A K, Barnes C, Yedjou C, et al. Oxidative stress, DNA damage, and antioxidant enzyme activity induced by hexavalent chromium in Sprague-Dawley rats[J]. Environmental Toxicology, 2009,24(1):66-73.
[6] Soudani N, Sefi M, Ben Amarai, et al. Protective effects of Selenium (Se) on Chromium (VI) induced nephrotoxicity in adult rats[J]. Ecotoxicology and Environmental Safety, 2010,73(4):671-678.
[7] D'amico G, Bazzi C. Urinary protein and enzyme excretion as markers of tubular damage[J]. Current Opinion in Nephrology and Hypertension, 2003,12(6):639-643.
[8] Lim S, Yoon J H. Exposure to environmental pollutants and a marker of early kidney injury in the general population:Results of a nationally representative cross-sectional study based on the Korean National Environmental Health Survey (KoNEHS) 2012~2014[J]. The Science of the Total Environment, 2019,681:175-182.
[9] Jung M S, Kim J Y, Lee H S, et al. Air pollution and urinary n-acetyl-B-glucosaminidase levels in residents living near a cement plant[J]. Annals of Occupational and Environmental Medicine, 2016,28:52.
[10] Lu C A, Zhang J F, Jiang H M, et al. Assessment of soil contamination with Cd, Pb and Zn and source identification in the area around the Huludao Zinc Plant[J]. Journal of Hazardous Materials, 2010,182(1-3):743-748.
[11] Wu S, Xia X, Lin C, et al. Levels of arsenic and heavy metals in the rural soils of Beijing and their changes over the last two decades (1985~2008)[J]. Journal of Hazardous Materials, 2010,179(1-3):860-868.
[12] Xu X, Nie S, Ding H, et al. Environmental pollution and kidney diseases[J]. Nature Reviews Nephrology, 2018,14(5):313-324.
[13] 郭慧芬.环境汞、铅、镉污染对居民健康的影响[D]. 山西医科大学, 2007. Guo H F. The effects on the residents' health induced by the heavy metal mercury, lead and cadmium in the environment[D]. Taiyuan:Shanxi Medical University, 2007.
[14] 胡建安,凌之琰,陈广湘,等.铅作业工人尿中N-乙酰-β-D-葡萄糖苷酶活性研究[J]. 中华劳动卫生职业病杂志, 1993,(4):27-29,65-66. Hu J A, Ling Z Y, Cheng G X, et al. Study on N-acetyl-β-D-glucosidase activity in the urine of lead workers[J]. Chinese Journal of Industrial Hygiene and Occupational Diseases, 1993,(4):27-29,65-66.
[15] 赵焕虎,王齐,陈建伟,等.镉暴露人群早期肾损伤指标敏感性比较[J]. 中国公共卫生, 2009,25(8):975-976. Zhao H H, Wang Q, Cheng J W, et al. Comparison of sensitivity of early kidney injury indicators in cadmium-exposed people[J]. Chinese Public Health, 2009,25(8):975-976.
[16] 袁宇纲,吴硕.环境镉暴露中止后的尿、头发、血液镉浓度和肾小管及肾小球功能的关联[J]. 国外医学(医学地理分册), 2001,(2):92-93. Yuan Y G, Wu S. Association between urine, hair, and blood cadmium concentrations and tubular and glomerular function after environmental cadmium exposure is discontinued[J]. Medicine Abroad (Medical Geography Fascicle), 2001,(2):92-93.
[17] 顾永恩.长期铬酸盐职业接触者的肾功能损伤研究[J]. 中华预防医学杂志, 2012,(3):240. Gu Y E. Study of renal impairment in long-term occupational exposure of chromate[J]. Chinese Journal of Preventive Medicine, 2012,46(3):240.
[18] 邓健,许金生,袁亚莉,等.铬作业工人尿NAG活性的研究[J]. 中国公共卫生, 1999,(5):62-63. Deng J, Xu J S, Yuan Y L, et al. Study of urinary NAG activity in chromium workers[J]. Chinese Public Health, 1999,(5):62-63.
[19] Köse Akzkydbygosk. Association between urinary indicators of renal dysfunction and metal concentrations in workers chronically co-exposed to cadmium, zinc and lead[J]. Biomarkers:biochemical indicators of exposure, response, and susceptibility to chemicals, 2001,6(5):351-356.
[20] Czarnota J, Gennings C, Colt J S, et al. Analysis of Environmental Chemical Mixtures and Non-Hodgkin Lymphoma Risk in the NCI-SEER NHL Study[J]. Environmental Health Perspectives, 2015, 123(10):965-970.
[21] Czarnota J, Gennings C, Wheeler D C. Assessment of weighted quantile sum regression for modeling chemical mixtures and cancer risk[J]. Cancer Informatics, 2015,14(Suppl 2):159-171.
[22] Carrico C, Gennings C, Wheeler D C, et al. Characterization of Weighted Quantile Sum Regression for Highly Correlated Data in a Risk Analysis Setting[J]. Journal of Agricultural, Biological, and Environmental Statistics, 2015,20(1):100-120.
[23] 刘彦良,高雅,任育智,等.甘肃白银厂及外围地区1:5万地球化学特征及找矿远景[J]. 新疆地质, 2021,39(3):431-437. Liu Y L, Gao Y, Ren Y Z, et al. Gansu silver factory and peripheral areas 1:50,000geochemical characteristics and prospecting prospects[J]. Geology of Xinjiang, 2021,39(3):431-437.
[24] 张丹,邓永怀,杜蓉.白银市东大沟流域突发水环境风险评估与管理[J]. 甘肃冶金, 2021,43(3):73-75. Zhang D, Deng Y H, Du R. Risk assessment and management of water emergencies in the Dongdagou River Basin of Baiyin City[J]. Gansu metallurgy, 2021,43(3):73-75.
[25] 张钊熔,段星星,夏明哲.白银东大沟水体和底泥中重金属污染评价[J]. 物探与化探, 2019,43(3):649-657. Zhang Z R, Duan X X, Xia M Z. Evaluation of heavy metal pollution in water and sediment in Baiyin East Dagou[J]. Geophysical and geochemical exploration, 2019,43(3):649-657.
[26] 陈伟,王婷.白银市污灌区土壤-小麦系统镉赋存特征及其健康风险评价[J]. 核农学报, 2020,34(4):878-886. Cheng W, Wang T. Cadmium occurrence characteristics and health risk evaluation of soil-wheat system in sewage irrigation area of Baiyin City[J]. Journal of Nuclear Agricultural Sciences, 2020,34(4):878-886.
[27] 柳依依.血浆金属浓度与肾功能下降的关联性研究[D]. 武汉:华中科技大学, 2018. Liu Y Y. Study of the association between plasma metal concentration and decreased renal function[D]. Wuhan:Huazhong University of Science and Technology, 2018.
[28] Gibson Sl, Mackenzie J C, Goldberg A. The diagnosis of industrial lead poisoning[J]. British Journal of Industrial Medicine, 1968,25(1):40-51.
[29] 张科.多金属暴露与冠心病患病风险及相关脏器功能的关联研究[D]. 华中科技大学, 2019. Zhang K. Association between polymetallic exposure and risk of coronary heart disease and related organ function[D]. Wuhan:Huazhong University of Science and Technology, 2019.
[30] 苏亮,陆峥.2017年中国失眠症诊断和治疗指南解读[J]. 世界临床药物, 2018,39(4):217-222. Su L, Lu Z. Interpretation of the 2017 Chinese guidelines for the diagnosis and treatment of insomnia[J]. World Clinical Medicine, 2018,39(4):217-222.
[31] 徐刚.尿蛋白与尿肌酐的比值、β_2微球蛋白及视黄醇结合蛋白联合检测对糖尿病肾病的早期诊断价值[J]. 实用临床医药杂志, 2020,24(21):86-89. Xu G. The ratio of urine protein to urine creatinine, the value of β_2 microglobulin and retinol-binding protein in the early diagnosis of diabetic nephropathy[J]. Journal of Practical Clinical Medicine, 2020,24(21):86-89.
[32] 陈建栋,陈建中.2型糖尿病患者血清CEA、SCC、CYFRA21-1水平与尿NAG关系的研究[J]. 标记免疫分析与临床, 2020,27(4):552-555. Cheng J D, Cheng J Z. A study on the relationship between serum CEA, SCC, CYFRA21-1levels and urine NAG in patients with type 2diabetes[J]. Labeled immunoassay and clinical, 2020,27(4):552-555.
[33] 孙敏.焦化厂工人苯、砷和铅暴露与健康指标的关联研究[D]. 太原:山西医科大学, 2020. Sun M. Association between benzene, arsenic and lead exposure to health indicators in coking plant workers[D]. Taiyuan:Shanxi Medical University, 2020.
[34] 汤冲,刘洪涛,郭丽曼,等.广东省健康人群血液中34种金属元素含量及年龄差异分析[J]. 广东医学, 2016,37(16):2465-2470. Tang C, Liu H T, Guo L M, et al. Analysis of blood content and age differences of 34metal elements in healthy people in Guangdong Province[J]. Guangdong Medicine, 2016,37(16):2465-2470.
[35] 惠晓芬,丁勇,张同军,等.陕西省一般人群全血和尿液中铬、镉和铅负荷水平分析[J]. 现代预防医学, 2020,47(19):3583-3588. Hui X F, Ding Y, Zhang T J, et al. Analysis of chromium, cadmium and lead load levels in whole blood and urine in the general population of Shaanxi Province[J]. Modern preventive medicine, 2020,47(19):3583-3588.
[36] Kim N H, Hyun Y Y, Lee K B, et al. Environmental heavy metal exposure and chronic kidney disease in the general population[J]. Journal of Korean Medical Science, 2015,30(3):272-277.
[37] 黄芸,袁洪,黄志军,等.环境重金属暴露对人群健康危害研究进展[J]. 中国公共卫生, 2016,32(8):1113-1116. Huang Y, Yuan H, Huang Z J, et al. Research progress on the health hazards of environmental heavy metal exposure to the population[J]. Chinese Public Health, 2016,32(8):1113-1116.
[38] 徐素仿,钱芳,邵静,等.尿mAlb、α_1-MG、β_2-MG联合检测在职业性铅中毒肾损伤早期诊断中的临床应用[J]. 职业卫生与应急救援, 2019,37(6):556-558. Xu S F, Qian F, Shao J, et al. Clinical application of urine mAlb, α_1-MG and β_2-MG in the early diagnosis of renal injury in occupational lead poisoning[J]. Occupational health and emergency rescue, 2019,37(6):556-558.
[39] 陈娟,明迪尧,何伟,等.湘江流域土壤高镉地区人群肾损伤调查[J]. 环境与健康杂志, 2019,36(8):703-708. Chen J, Ming D Y, He W, et al. Investigation of kidney injury in the population in areas with high cadmium in the Xiangjiang River Basin[J]. Journal of Environment and Health, 2019,36(8):703-708.
[40] Yuan T H, Jhuang M J, Yeh Y P, et al. Relationship between renal function and metal exposure of residents living near the No. 6 Naphtha Cracking Complex:A cross-sectional study[J]. Journal of the Formosan Medical Association, 2021,120(10):1845-1854.
[41] Cabral M, Garçon G, Touré A, et al. Renal impairment assessment on adults living nearby a landfill:Early kidney dysfunction biomarkers linked to the environmental exposure to heavy metals[J]. Toxicology Reports, 2021,8:386-394.
[42] Tsai H J, Hung C H, Wang C W, et al. Associations among heavy metals and proteinuria and chronic kidney disease[J]. Diagnostics (Basel, Switzerland), 2021,11(2):282.
[43] Levin-Schwartz Y, Claus Hennb, Gennings C, et al. Integrated measures of lead and manganese exposure improve estimation of their joint effects on cognition in Italian school-age children[J]. Environment International, 2021,146:106312.
[44] 杨杏芬,吴永宁.镉对人群健康效应研究需要注重肾损害水平之下的低剂量暴露[J]. 中华预防医学杂志, 2016,50(4):292-295. Yang X F, Wu Y N. Studies of the effects of cadmium on population health need to focus on low-dose exposure below the level of renal impairment[J]. Chinese Journal of Preventive Medicine, 2016,50(4):292-295.
[45] Hu W, Wang Y, Wang T, et al. Ambient particulate matter compositions and increased oxidative stress:Exposure-response analysis among high-level exposed population[J]. Environment International, 2021, 147:106341.
[46] Zhao M, Xu J, Li A, et al. Multiple exposure pathways and urinary chromium in residents exposed to chromium[J]. Environment International, 2020,141:105753.