Effects of short-term exposure to PM2.5 and PM10 on blood pressure in adults in Jinchang City
ZHANG Li1, SHI Guo-xiu1, LIU Yan-li1, WANG Min-zhen1, ZHANG Xiao-fei1, Lü Kang1, KANG Feng2, BAI Ya-na1, ZHENG Shan1
1. Institute of Epidemiology and Statistics, School of Public Health, Lanzhou University, Lanzhou 730000, China; 2. Workers'Hospital of Jinchuan Group Co. Ltd, Jinchang 737100, China
Abstract：In order to explore the effect of short-term exposure to particulate matter (PM) on blood pressure (BP) level in northwest China, based on the Jinchang cohort platform, the data on the particulate pollution of Jinchang City and BP measurement of cohort population from 2011 to 2017 were collected. After adjusting for relevant confounding factors, a linear mixed-effect model was used to analyze the effects of short-term exposure to PM2.5 and PM10 on systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), Pulse pressure (PP) and Mid-BP (the mean of SBP and DBP). The results showed that with the increase of PM2.5 concentration, the levels of SBP, MAP, PP and Mid-BP all showed an upward trend, and their largest effects were found at the cumulative lag 05, 03, 07 and 05 days, respectively. With the increase of PM10 concentration, the five BP indicators all showed an upward trend, and their largest effects all appeared at cumulative lag 07 days. The effect of PM2.5 and PM10 on BP were more significant in smoker and male. In addition, dust weather and gaseous pollutants (SO2 and NO2) had a certain effect modification on the PM-BP effect. Therefore, there was an adverse effect of short-term exposure to PM2.5 and PM10 on people’s BP, smokers and males may be susceptible to the effect of PM on BP.
张丽, 石国秀, 刘艳丽, 王敏珍, 张晓飞, 吕康, 康峰, 白亚娜, 郑山. 金昌市PM2.5及PM10短期暴露对成人血压水平的影响[J]. 中国环境科学, 2022, 42(7): 3450-3460.
ZHANG Li, SHI Guo-xiu, LIU Yan-li, WANG Min-zhen, ZHANG Xiao-fei, Lü Kang, KANG Feng, BAI Ya-na, ZHENG Shan. Effects of short-term exposure to PM2.5 and PM10 on blood pressure in adults in Jinchang City. CHINA ENVIRONMENTAL SCIENCECE, 2022, 42(7): 3450-3460.
Wolf K, Schneider A, Breitner S, et al. Associations between short-term exposure to particulate matter and ultrafine particles and myocardial infarction in Augsburg, Germany[J]. International Journal of Hygiene and Environmental Health, 2015,218(6):535-542.
[2]
Li H C, Chen R J, Meng X, et al. Short-term exposure to ambient air pollution and coronary heart disease mortality in 8Chinese cities[J]. International Journal of Cardiology, 2015,197:265-270.
[3]
Du Y X, Xu X H, Chu M, et al. Air particulate matter and cardiovascular disease:the epidemiological, biomedical and clinical evidence[J]. Journal of Thoracic Disease, 2016,8(1):E8-E19.
[4]
Patel P, Ordunez P, Dipette D, et al. Improved blood pressure control to reduce cardiovascular disease morbidity and mortality:The standardized hypertension treatment and prevention project[J]. Journal of Clinical Hypertension, 2016,18(12):1284-1294.
[5]
Cakmak S, Dales R, Leech J, et al. The influence of air pollution on cardiovascular and pulmonary function and exercise capacity:Canadian Health Measures Survey (CHMS)[J]. Environmental Research, 2011,111(8):1309-1312.
[6]
Dvonch J T, Kannan S, Schulz A J, et al. Acute effects of ambient particulate matter on blood pressure differential effects across urban communities[J]. Hypertension, 2009,53(5):853-859.
[7]
Chuang K J, Yan Y H, Cheng T J. Effect of air pollution on blood pressure, blood lipids, and blood sugar:A population-based approach[J]. Journal of Occupational and Environmental Medicine, 2010,52(3):258-262.
[8]
Zeng X W, Qian Z M, Vaughn M G, et al. Positive association between short-term ambient air pollution exposure and children blood pressure in China Result from the Seven Northeast Cities (SNEC) study[J]. Environmental Pollution, 2017,224:698-705.
[9]
Yang H B, Teng C G, Hu J, et al. Short-term effects of ambient particulate matter on blood pressure among children and adolescents:A cross-sectional study in a city of Yangtze River delta, China[J]. Chemosphere, 2019,237.
[10]
徐勇勇,尚磊,杜晓晗.我国17~21岁男青年血压水平的地区差异[J].疾病控制杂志, 2003,(3):189-193. Xu Y Y, Shang L, Du X B. Regional differences in blood pressure levels among young men aged 17~21 in my country[J]. Journal of Disease Control, 2003,(3):189-193.
[11]
Arslan S, Arslan N, Soylu A, et al. High altitude and blood pressure in children.[J]. The Yale journal of biology and medicine, 2003,76(4-6):145-148.
[12]
杨丽丽,陶会杰,李晓云,等.金昌市环境空气质量变化趋势预测与评价[J].环境与发展, 2021,33(3):157-162. Yang L L, Tao H J, Li X Y, et al. Prediction and evaluation of change trend of ambient air quality in Jinchang City[J]. Environment and Development, 2021,33(3):157-162.
[13]
Bai Y N, Yang A M, Pu H Q, et al. Cohort profile:The China metalexposed workers cohort study (Jinchang Cohort)[J]. International Journal of Epidemiology, 2017,46(4):1095-1096e.
[14]
Stoffel M A, Nakagawa S, Schielzeth H. rptR:repeatability estimation and variance decomposition by generalized linear mixed-effects models[J]. Methods in Ecology and Evolution, 2017,8(11):1639-1644.
[15]
Zeka A, Zanobetti A, Schwartz J. Individual-level modifiers of the effects of particulate matter on daily mortality[J]. American Journal of Epidemiology, 2006,163(9):849-859.
[16]
Li J, Woodward A, Hou X Y, et al. Modification of the effects of air pollutants on mortality by temperature:A systematic review and meta-analysis[J]. Science of the Total Environment, 2017,575:1556-1570.
[17]
Zhang H W, Qian J, Zhao H P, et al. A study of the association between atmospheric particulate matter and blood pressure in the population[J]. Blood Pressure, 2016,25(3):169-176.
[18]
Li N, Chen G B, Liu F F, et al. Associations between long-term exposure to air pollution and blood pressure and effect modifications by behavioral factors[J]. Environmental Research, 2020,182.
[19]
Yang B Y, Qian Z M, Howard S W, et al. Global association between ambient air pollution and blood pressure:A systematic review and meta-analysis[J]. Environmental Pollution, 2018,235:576-588.
[20]
Tsai D H, Riediker M, Wuerzner G, et al. Short-term increase in particulate matter blunts nocturnal blood pressure dipping and daytime urinary sodium excretion[J]. Hypertension, 2012,60(4):1061-1069.
[21]
Tsai D H, Guessous I, Riediker M, et al. Short-term effects of particulate matters on pulse pressure in two general population studies[J]. Journal of Hypertension, 2015,33(6):1144-1152.
[22]
Chuang K J, Yan Y H, Chiu S Y, et al. Long-term air pollution exposure and risk factors for cardiovascular diseases among the elderly in Taiwan[J]. Occupational and Environmental Medicine, 2011,68(1):64-68.
[23]
Shah A S V, Lee K K, Mcallister D A, et al. Short term exposure to air pollution and stroke:systematic review and meta-analysis[J]. Bmj-British Medical Journal, 2015,350.
[24]
Mustafic H, Jabre P, Caussin C, et al. Main air pollutants and myocardial infarction a systematic review and meta-analysis[J]. Jama-Journal of the American Medical Association, 2012,307(7):713-721.
[25]
Cai Y Y, Zhang B, Ke W X, et al. Associations of Short-Term and Long-Term Exposure to Ambient Air Pollutants With Hypertension A Systematic Review and Meta-Analysis[J]. Hypertension, 2016, 68(1):62-70.
[26]
Lim S S, Vos T, Flaxman A D, et al. A comparative risk assessment of burden of disease and injury attributable to 67risk factors and risk factor clusters in 21regions, 1990~2010:a systematic analysis for the Global Burden of Disease Study 2010[J]. Lancet, 2012,380(9859):2224-2260.
[27]
Franklin S S, Lopez V A, Wong N D, et al. Single versus combined blood pressure components and risk for cardiovascular disease the framingham heart study[J]. Circulation, 2009,119(2):243-U269.
[28]
Hao G, Wang X L, Treiber F A, et al. Blood pressure trajectories from childhood to young adulthood associated with cardiovascular risk results from the 23-Year longitudinal georgia stress and heart study[J]. Hypertension, 2017,69(3):435-442.
[29]
Allen N B, Siddique J, Wilkins J T, et al. Blood pressure trajectories in early adulthood and subclinical atherosclerosis in middle age[J]. Jama-Journal of the American Medical Association, 2014,311(5):490-497.
[30]
Whelton P K, Carey R M, Aronow W S, et al. 2017ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the prevention, detection, evaluation, and management of high blood pressure in adults:Executive summary:A report of the american college of cardiology/American Heart Association task force on clinical practice guidelines[J]. Journal of the American Society of Hypertension:JASH, 2018,12(8):579.e571-579.e573.
[31]
Zhang L C, An J, Tian X, et al. Acute effects of ambient particulate matter on blood pressure in office workers[J]. Environmental Research, 2020,186.
[32]
Wang C C, Chen R J, Cai J, et al. Personal exposure to fine particulate matter and blood pressure:A role of angiotensin converting enzyme and its DNA methylation[J]. Environment International, 2016,94:661-666.
[33]
Honda T, Pun V C, Manjourides J, et al. Associations of of long-term fine particulate matter exposure with prevalent hypertension and increased blood pressure in older Americans[J]. Environmental Research, 2018,164:1-8.
[34]
Auchincloss A H, Roux A V D, Dvonch J T, et al. Associations between recent exposure to ambient fine particulate matter and blood pressure in the Multi-Ethnic Study of Atherosclerosis (MESA)[J]. Environmental Health Perspectives, 2008,116(4):486-491.
[35]
Brook R D, Bard R L, Burnett R T, et al. Differences in blood pressure and vascular responses associated with ambient fine particulate matter exposures measured at the personal versus community level[J]. Occupational and Environmental Medicine, 2011,68(3):224-230.
[36]
Winkelmann B R, Von Holt K, Unverdorben M. Smoking and atherosclerotic cardiovascular disease:Part II:Role of cigarette smoking in cardiovascular disease development[J]. Biomarkers in Medicine, 2009,3(5):617-653.
[37]
Talukder M A H, Johnson W M, Varadharaj S, et al. Chronic cigarette smoking causes hypertension, increased oxidative stress, impaired NO bioavailability, endothelial dysfunction, and cardiac remodeling in mice[J]. American Journal of Physiology-Heart and Circulatory Physiology, 2011,300(1):H388-H396.
[38]
贾雪芹,杜秀丽,许敏,等.长期饮酒对男性高血压患者血压晨峰的影响及与左室肥厚的相关性[J].第二军医大学学报, 2016,37(9):1115-1120. Jia X Q, Du X L, Xu M, et al. Effects of long-term drinking on morning blood pressure peaks in male hypertensive patients and its correlation with left ventricular hypertrophy[J]. Journal of the Second Military Medical University, 2016,37(9):1115-1120.
[39]
Klatsky A L. Alcohol-associated hypertension-When one drinks makes a difference[J]. Hypertension, 2004,44(6):805-806.
[40]
Chen S Y, Su T C, Lin Y L, et al. Short-term effects of air pollution on pulse pressure among nonsmoking adults[J]. Epidemiology, 2012, 23(2):341-348.
[41]
Clougherty J E. A growing role for gender analysis in air pollution epidemiology[J]. Environmental Health Perspectives, 2010,118(2):167-176.
[42]
Sood A, Cui X, Qualls C, et al. Association between asthma and serum adiponectin concentration in women[J]. Thorax, 2008,63(10):877-882.
[43]
Brauner E V, Mortensen J, Moller P, et al. Effects of ambient air particulate exposure on blood-gas barrier permeability and lung function[J]. Inhalation Toxicology, 2009,21(1):38-47.
[44]
孙兆彬,安兴琴,崔甍甍,等.北京地区颗粒物健康效应研究——沙尘天气、非沙尘天气下颗粒物(PM2.5、PM1.)对心血管疾病入院人次的影响[J].中国环境科学, 2016,36(8):2536-2544. Sun Z B, An X Q, Cui L L, et al. Study on the health effects of particulate matter in Beijing:the impact of particulate matter (PM2.5, PM10) on admissions to cardiovascular disease in sandy and non-dusty weather[J]. China Environmental Science, 2016,36(8):2536-2544.
[45]
翁俊,韦性富,聂永红,等.颗粒物污染对高血压门急诊就诊人数的影响-时间序列研究[J].中国环境科学, 2018,38(7):2751-2757. Weng J, Wei X F, Nie Y H, et al. Effects of particulate matter pollution on the number of outpatient and emergency department visits for hypertension:a time series study[J]. China Environmental Science, 2018,38(7):2751-2757.
[46]
Jayaratne E R, Johnson G R, Mcgarry R, et al. Characteristics of airborne ultrafine and coarse particles during the Australian dust storm of 23September 2009[J]. Atmospheric Environment, 2011,45(24):3996-4001.
[47]
Stafoggia M, Samoli E, Alessandrini E, et al. Short-term associations between fine and coarse particulate matter and hospitalizations in Southern Europe:Results from the MED-PARTICLES Project[J]. Environmental Health Perspectives, 2013,121(9):1026-1033.
[48]
Zeger S L, Thomas D, Dominici F, et al. Exposure measurement error in time-series studies of air pollution:concepts and consequences[J]. Environmental Health Perspectives, 2000,108(5):419-426.
[49]
Giorginia P, Di Giosia P, Grassi D, et al. Air pollution exposure and blood pressure:An updated review of the literature[J]. Current Pharmaceutical Design, 2016,22(1):28-51.
[50]
Bellavia A, Urch B, Speck M, et al. DNA hypomethylation, ambient particulate matter, and increased blood pressure:Findings from controlled human exposure experiments[J]. Journal of the American Heart Association, 2013,2:e000212.
[51]
Stork J, Schrader J, Mann H, et al. The effect of mental work on The diurnalvariations of blood-pressure[J]. Nieren-Und Hochdruckkrankheiten, 1992, 21(10):466-468.
[52]
Fuks K B, Weinmayr G, Basagana X, et al. Long-term exposure to ambient air pollution and traffic noise and incident hypertension in seven cohorts of the European study of cohorts for air pollution effects (ESCAPE)[J]. European Heart Journal, 2017,38(13):983-990.
