The required techniques are investigated for applying the Tsinghua MEIC emission inventory of 2012 reference year with 0.25°×0.25° resolution to the WRF-CHEM model. These techniques include the calculation of pollutant mass per unit area, the transformation of pollutant concentration from the lat-lon grid to the mesoscale grid, the refinement of emission inventory with model land-use data, the determination of hourly emission data in each sector, and the apportionment of major PM_2.5 species in the specified regions. The effectiveness and performance of the aforementioned inventory processing techniques are assessed in the heavy pollution scenarios.It is indicated that the local accumulation and horizontal transport of pollutants can be well simulated from the WRF-CHEM model. However, the concentration in the high pollution central area is underestimated, which is closely related to the forecast bias in the meteorological fields. Additionally, the refinement of emission inventory changes the simulated pollutant concentration. The amount of change is found to vary according to the weather conditions. Under stable meteorological conditions, large changes mainly occur within and around urban areas.