PFOS及其三种替代品对蚯蚓的毒性效应及比较

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摘要本研究从氧化应激、生殖毒性和发育毒性3个方面研究了PFOS、6:2FTSA、PFHxS和PFBS以相同浓度(0.2mg/kg)暴露28d后对赤子爱胜蚓的毒性效应.结果表明,PFOS、6:2FTSA、PFHxS和PFBS均诱导ROS含量上升,并导致脂质过氧化和DNA损伤.此外,PFOS及其3种替代品还诱导与氧化应激、生殖和生长发育相关的基因异常表达,从而在基因水平上诱导氧化应激并引发生殖毒性和发育毒性.综合生物标志物响应(IBR)指数结果表明,PFOS、6:2FTSA、PFHxS和PFBS的IBR数值分别为36.4, 22.2, 34.1, 24.3. 4种物质对蚯蚓的综合毒性大小依次为:PFOS>PFHxS>PFBS>6:2FTSA,表明3种替代品的综合毒性低于PFOS.本研究结果为6:2FTSA、PFHxS和PFBS作为PFOS替代品的安全性评价提供了依据.

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	李登昙
	卢成波
	王晓乐
	杜仲坤
	李冰
	王金花
	王军
	张静文
	朱鲁生

关键词 ： PFOS替代品, 赤子爱胜蚓, 氧化应激, 发育毒性, 毒性比较

Abstract：The toxic effects of PFOS, 6:2 FTSA, PFHxS, and PFBS on Eisenia fetida were investigated in terms of oxidative stress, reproductive toxicity, and developmental toxicity after 28 days of exposure to the same concentration (0.2mg/kg). PFOS, 6:2 FTSA, PFHxS, and PFBS all caused an increase in ROS content and led to lipid peroxidation and DNA damage. In addition, PFOS and its three alternatives also induced abnormal gene expression related to oxidative stress, reproduction, and growth and development. Thus inducing oxidative stress and triggering reproductive toxicity, and developmental toxicity at the genetic level. The results of integrated biomarker response (IBR) index showed that the IBR values of PFOS, 6:2 FTSA, PFHxS and PFBS were 36.4, 22.2, 34.1, and 24.3, respectively. The combined toxicity of the four substances to earthworms was in the following order: PFOS>PFHxS>PFBS>6:2 FTSA, which indicated that the combined toxicity of the three alternatives was lower than that of the PFOS. The results of this study provided a basis for the safety evaluation of 6:2 FTSA, PFHxS, and PFBS as alternatives to PFOS.

Key words： PFOS alternatives eisenia fetida oxidative stress developmental toxicity toxicity comparison

收稿日期: 2023-12-15

PACS:

X503.2

基金资助:国家自然科学基金资助项目(42077042)

作者简介: 李登昙(1997-),女,山东济宁人,山东农业大学硕士研究生.研究方向为污染物环境行为与效应.发表论文2篇.lidengtan26@163.com.

引用本文:

李登昙, 卢成波, 王晓乐, 杜仲坤, 李冰, 王金花, 王军, 张静文, 朱鲁生. PFOS及其三种替代品对蚯蚓的毒性效应及比较[J]. 中国环境科学, 2024, 44(3): 1630-1637. LI Deng-tan, LU Cheng-bo, WANG Xiao-le, DU Zhong-kun, LI Bing, WANG Jin-hua, WANG Jun, ZHANG Jing-wen, ZHU Lu-sheng. Toxic effects and comparison of PFOS and its three alternatives on earthworms. CHINA ENVIRONMENTAL SCIENCECE, 2024, 44(3): 1630-1637.

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http://www.zghjkx.com.cn/CN/ 或 http://www.zghjkx.com.cn/CN/Y2024/V44/I3/1630

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