In orderto investigate the enrichment of bisphenol F (BPF) and bisphenol S (BPS) in zebrafish and their combined neurotoxicity, single and combined exposure of 1, 10, 100, 1000μg/L BPF and BPS was conducted for 14days. The enrichment level of BPF and BPS in zebrafish tissues was positively correlated with the exposure concentration and time, and the enrichment capacity of BPF was higher than that of BPS. Combined exposure of BPF and BPS reduced the enrichment level of BPS in zebrafish, but had little effects on the enrichment of BPF. Toxicity studies on brain tissues showed that BPF induced levels of oxidative damage and inflammation indicators such as malondialdehyde (MDA), 8-hydroxy-2'-deoxyguanosine (8-OHdG), interleukin-1β(1L-1β) and tumor necrosis factor α (TNF-α), were higher than those of BPS. Moreover, combined exposure was found to have toxicity enhancement effects. However, the toxic effects of BPS on neurotoxic markers, such as cortisol (COR), epinephrine (EPI) and acetylcholinesterase (AChE), and genes related to neurological functions, such as Syn2a, MBP, Gfap, MAP2, NSE2 and S-100B, were higher than those of BPF. And, combined exposure reduced the effects on AChE, COR and EPI.
王倩倩, 王永花, 汪贝贝, 刘晓丹, 吴兵, 陆光华. 双酚F和双酚S联合暴露下的斑马鱼富集及神经毒性[J]. 中国环境科学, 2020, 40(2): 865-873.
WANG Qian-qian, WANG Yong-hua, WANG Bei-bei, LIU Xiao-dan, WU Bing, LU Guang-hua. ccumulation and neurotoxicity of bisphenol F and bisphenol S in zebrafish under combined exposure. CHINA ENVIRONMENTAL SCIENCECE, 2020, 40(2): 865-873.
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