Effect of chorionic villi on the combination action of microplastic particles and cadmium
DUAN Xin-yue1, GUAN Wen-ling1, CHENG Hao-dong1, DAI Yuan-yuan2, WANG Lei3, DUAN Zheng-hua1,3
1. School of Environmental Science and Safety Engineering, Tianjin University of Technology, Tianjin 300384, China; 2. Fisheries Research Institute of Tianjin, Tianjin 300221, China; 3. College of Environmental Science and Engineering, Nankai University, Tianjin 300350, China
Abstract：Polystyrene (PS) particles with sizes of 100nm (n-PS) and 70~250μm (μ-PS) were used to investigate their influences on the developmental toxicity of cadmium (Cd). The technologies of embryonic development and metabonomics were utilized to analysis the interaction between microplastic particles and embryonic chorion. In single Cd, n-PS+Cd, and μ-PS+Cd treatments, the contents of Cd on embryonic chorion were 3.82, 13.66 and 11.35mg/g, respectively, and the contents of Cd in embryos were 0.24, 0.16 to 0.20mg/g, respectively. The accumulations of Cd increased on embryonic chorion and decreased in embryos were more significantly induced by n-PS (P<0.01). However, μ-PS inhibited the embryonic development toxicity of Cd to a greater extent (P=0.006). Metabonomics data confirmed that, the oxidative stress on embryos and the demand for cellular energy induced by Cd were increased in the combined treatment of Cd and n-PS, which might be due to the barrier action of n-PS on embryonic chorion. Therefore, embryonic chorion plays an important role in the early embryonic development toxicities of microplastics. This study will provide some new sights on the research of bio-availability and effect of microplastics in the environment.
Wang L, Zhang J, Hou S, et al. A simple method for quantifying polycarbonate and polyethylene terephthalate microplatics in environmental samples by liquid chromatography-tandem mass spectrometry[J]. Environmental Science & Technology Letters, 2017, 4(12):530-534.
[2]
Yu X, Peng J, Wang J, et al. Occurrence of microplastics in the beach sand of the Chinese inner sea:the Bohai Sea[J]. Environmental Pollution, 2016,214:722-730.
[3]
Peng G, Zhu B, Yang D, et al. Microplastics in sediments of the Changjiang Estuary, China[J]. Environmental Pollution, 2017,225:283-290.
[4]
王佳佳,赵娜娜,李金惠.中国海洋微塑料污染现状与防治建议[J]. 中国环境科学, 2019,39(7):3056-3063. Wang J, Zhao N, Li J. Current situation of marine microplastics pollution and prevention proposals in China[J]. China Environmental Science, 2019,39(7):3056-3063
[5]
周倩,田崇国,骆永明.滨海城市大气环境中发现多种微塑料及其沉降通量差异[J]. 科学通报, 2017,62(33):3902-3909. Zhou Q, Tian C, Luo Y. Various forms and deposition fluxes of microplastics identified in the coastal urban atmosphere[J]. Chinese Science Bulletin, 2017,62(33):3902-3909.
[6]
Zhao S, Zhu L, Li D. Characterization of small plastic debris on tourism beaches around the South China Sea[J]. Regional Studies in Marine Science, 2015,1:55-62.
[7]
Duan Z, Zhao S, Zhao L, et al. Microplastics in Yellow River Delta wetland:Occurrence, characteristics, human influences, and marker[J]. Environmental Pollution, 2020,258:113232.
[8]
Yang D, Shi H, Li L, et al. Microplastic pollution in table salts from China[J]. Environmental Science & Technology, 2015,49(22):13622-13627.
[9]
Duan Z, Xing Y, Feng Z, et al. Hepatotoxicity of benzotriazole and its effect on the cadmium induced toxicity in zebrafish Danio rerio [J]. Environmental Pollution, 2017,224:706-713.
[10]
Wang C, Wei Z, Han Z, et al. Neutrophil extracellular traps promote cadmium chloride-induced lung injury in mice[J]. Environmental Pollution, 2019,254(Pt A):113021.
[11]
Li S, Baiyun R, Lv Z, et al. Exploring the kidney hazard of exposure to mercuric chloride in mice:disorder of mitochondrial dynamics induces oxidative stress and results in apoptosis[J]. Chemosphere, 2019,234:822-829.
[12]
Kedzierski M, D'Almeida M, Magueresse A, et al. Threat of plastic ageing in marine environment:Adsorption/desorption of micropollutants[J]. Marine Pollution Bulletin, 2018,127:684-694.
[13]
付东东,张琼洁,范正权,等.微米级聚苯乙烯对铜的吸附特性[J]. 中国环境科学, 2019,39(11):4769-4775. Fu D, Zhang Q, Fan Z, et al. Adsorption characteristics of copper ions on polystyrene microplastics[J]. China Environmental Science, 2019,39(11):4769-4775.
[14]
Barboza L G A, Vieira L R, Branco V, et al. Microplastics cause neurotoxicity, oxidative damage and energy-related changes and interact with the bioaccumulation of mercury in the European seabass, Dicentrarchus labrax (Linnaeus, 1758)[J]. Aquatic Toxicology, 2018,195:49-57.
[15]
Kim D, Chae Y, An Y J. Mixture toxicity of nickel and microplastics with different functional groups on Daphnia magna[J]. Environmental Science & Technology, 2017,51(21):12852-12858.
[16]
Luís LG, Ferreira P, Fonte E, et al. Does the presence of micro plastics influence the acute toxicity of chromium (VI) to early juveniles of the common goby (Pomatoschistus microps)? A study with juveniles from two wild estuarine populations[J]. Aquatic Toxicology, 2015,164:163-167.
[17]
Kristofco L A, Haddad S P, Chambliss C K, et al. Differential uptake of and sensitivity to diphenhydramine in embryonic and larval zebrafish[J]. Environmental Toxicology and Chemistry, 2018,37(4):1175-1181.
[18]
Cheng J, Flahaut E, Cheng S H. Effect of carbon nanotubes on developing zebrafish (Danio rerio) embryos[J]. Environmental Toxicology and Chemistry, 2017,26(4):708-716.
[19]
Liegertová M, Wrobel D, Herma R, et al. Evaluation of toxicological and teratogenic effects of carbosilane glucose glycodendrimers in zebrafish embryos and model rodent cell lines[J]. Nanotoxicology, 2018,12(8):797-818.
[20]
Vranic S, Shimada Y, Ichihara S, et al. Toxicological evaluation of SiO2 nanoparticles by zebrafish embryo toxicity test[J]. International Journal of Molecular Sciences, 2019,20(4):882.
[21]
Duan Z, Duan X, Zhao S, et al. Barrier function of zebrafish embryonic chorions against microplastics and nanoplastics and its impact on embryo development[J]. Journal of Hazardous Materials, 2020,395:122621.
[22]
Lee W S, Cho H J, Kim E, et al. Bioaccumulation of polystyrene nanoplastics and their effect on the toxicity of Au ions in zebrafish embryos[J]. Nanoscale, 2019,11(7):3173-3185.
[23]
端正花,陈晓欧,刘灵丽,等.苯并三唑和镉对斑马鱼肝脏的联合毒性效应[J]. 中国环境科学, 2015,35(6):1872-1876. Duan Z, Chen X, Liu L, et al. Joint toxicity of benzotriazole and cadmium to zebrafish liver[J]. China Environmental Science, 2015, 35(6):1872-1876.
[24]
Ogunbileje J O, Nawgiri R S, Anetor J I, et al. Particles internalization, oxidative stress, apoptosis and pro-inflammatory cytokines in alveolar macrophages exposed to cement dust[J]. Environmental Toxicology and Pharmacology, 2014,37(3):1060-1070.
[25]
Wang S, Zhang Q, Zheng S, et al. Atrazine exposure triggers common carp neutrophil apoptosis via the CYP450s/ROS pathway[J]. Fish & shellfish immunology, 2019,84:551-557.
[26]
马思睿,李舒行,郭学涛.微塑料的老化特性、机制及其对污染物吸附影响的研究进展[J]. 中国环境科学, 2020,40(9):3992-4003. Ma S, Li S, Guo X. A review on aging characteristics, mechanism of microplastics and their effects on the adsorption behaviors of pollutants[J]. China Environmental Science, 2020,40(9):3992-4003.
[27]
Rienksma R A, Schaap P J, Martins Dos Santos V A P, et al. Modeling host-pathogen interaction to elucidate the metabolic drug response of intracellularmycobacterium tuberculosis[J]. Frontiers in Cellular and Infection Microbiology, 2019,9:144.
[28]
Cheng Z X, Guo C, Chen Z G, et al. Glycine, serine and threonine metabolism confounds efficacy of complement-mediated killing[J]. Nature Communications, 2019,10(1):3325.
[29]
Roy S, Rizvi Z A, Awasthi A. Metabolic checkpoints in differentiation of helper T cells in tissue inflammation[J]. Frontiers in Immunology, 2019,9:3036.
[30]
Saravia J, Raynor JL, Chapman NM, et al. Signaling networks in immunometabolism[J]. Cell Research, 2020,30(4):328-342.
[31]
Ong K J, Zhao X, Thistle M E, et al. Mechanistic insights into the effect of nanoparticles on zebrafish hatch[J]. Nanotoxicology, 2014, 8:295-304.
[32]
Chen Q, Gundlach M, Yang S, et al. Quantitative investigation of the mechanisms of microplastics and nanoplastics toward zebrafish larvae locomotor activity[J]. The Science of the Total Environment, 2017, 584:1022-1031.
[33]
van Pomeren M, Brun N R, Peijnenburg W J G M, et al. Exploring uptake and biodistribution of polystyrene (nano) particles in zebrafish embryos at different developmental stages[J]. Aquatic Toxicology, 2017,190:40-45.
[34]
Farrell P, Nelson K. Trophic level transfer of microplastic: Mytilus edulis (L.) to Carcinusmaenas (L.)[J]. Environmental Pollution, 2013,177C(4):1-3.
[35]
Du J, Xu S, Zhou Q, et al. A review of microplastics in the aquatic environmental:distribution, transport, ecotoxicology, and toxicological mechanisms[J]. Environmental Science and Pollution Research International, 2020,27(11):11494-11505.
[36]
Davarpanah E, Guilhermino L. Are gold nanoparticles and microplastics mixtures more toxic to the marine microalgae Tetraselmis chuii than the substances individually[J]. Ecotoxicology and Environmental Safety, 2019,181:60-68.
[37]
Ferreira P, Fonte E, Soares M E, et al. Effects of multi-stressors on juveniles of the marine fish Pomatoschistus microps:gold nanoparticles, microplastics and temperature[J]. Aquatic Toxicology, 2016,170:89-103.
[38]
Li J, Chapman E C, Shi H, et al. PVC does not influence cadmium uptake or effects in the Mussel (Mytilus edulis)[J]. Bulletin of Environmental Contamination and Toxicology, 2020,104(3):315-320.
