内分泌干扰物测试技术和评估体系

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摘要内分泌干扰物是近年来被学术界和国际社会高度关注的一大类污染物,对生态安全和人体健康存在已知的和潜在的危害.本研究介绍了目前国际公认的内分泌干扰物测试方法,主要涉及雌激素、雄激素和甲状腺通路的干扰活性测试;在分析不同级别方法的特点和局限性的基础上,指出内分泌干扰活性检测和不良效应评估不能很好关联是鉴别内分泌干扰物的技术瓶颈;进一步梳理了欧盟、美国等发达国家测试和评估内分泌干扰物的方案或策略,并由此比较了各自的特点和共性;在此基础上,分析了我国内分泌干扰物研究现状及存在的问题, 并就我国构建内分泌干扰物测试和评估体系提出几点建议.

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	宋峙嶙
	李圆圆
	熊忆茗
	李金波
	秦占芬

关键词 ：内分泌干扰物, 测试技术, 评估体系, 雌激素, 雄激素, 甲状腺激素

Abstract：Endocrine disrupting chemicals (EDCs) are a major kind of pollutants that have been highly concerned by the academia and the international community in recent years because of their known and potential hazards to ecological safety and human health. This paper introduces the currently widely recognized methods for testing EDCs, mainly involving the disrupting activities of estrogen, androgen and thyroid pathways. The characteristics and limitations of different levels of methods show that the detection of endocrine disrupting activity and the evaluation of adverse effects cannot be well correlated, which is the technical bottleneck in identifying EDCs. We further review the strategies for testing and assessing EDCs in developed countries such as the European Union and the United States and compare their characteristics and commonalities, from which we discussed the current situation and problems of EDCs research in China and provide some advices on the construction of testing and assessing system of EDCs in China.

Key words： endocrine disrupting chemicals testing technology assessing system estrogen androgen thyroid hormone

收稿日期: 2022-10-20

PACS:

X592

基金资助:国家自然科学基金资助项目(21876196)

通讯作者: 秦占芬,研究员,qinzhanfen@rcees.ac.cn E-mail: qinzhanfen@rcees.ac.cn

作者简介: 宋峙嶙(1998-),女,黑龙江黑河市人,中国科学院生态环境研究中心博士研究生,主要从事环境毒理学研究.songshilin21@mails.ucas.ac.cn.

引用本文:

宋峙嶙, 李圆圆, 熊忆茗, 李金波, 秦占芬. 内分泌干扰物测试技术和评估体系[J]. 中国环境科学, 2023, 43(5): 2601-2612. SONG Shi-lin, LI Yuan-yuan, XIONG Yi-ming, LI Jin-bo, QIN Zhan-fen. Testing techniques and assessment systems for endocrine disrupting chemicals. CHINA ENVIRONMENTAL SCIENCECE, 2023, 43(5): 2601-2612.

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http://www.zghjkx.com.cn/CN/ 或 http://www.zghjkx.com.cn/CN/Y2023/V43/I5/2601

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