Biotransformation of an organophosphate flame retardant V6 based on suspect screening technique
LI Jian-hua, ZHANG Ya-yun, MENG Wei-kun, SU Guan-yong
Jiangsu Key Laboratory of Chemical Pollution Control and Resources Reuse, School of Environmental and Biological Engineering, Nanjing University of Science and Technology, Nanjing 210094, China
Abstract：This study studied metabolism of V6 in human liver microsomes (HLM) using Orbitrap high-resolution mass spectrometer (Orbitrap-HRMS). With the exception of 5 reported metabolites including O-dealkylated, oxidative de-phospherylated and O- dechlorinated compounds, 6 novel products were firstly observed. Based on their MS/MS spectra, these newly discovered metabolites were identified as aldehyde and carboxyl products. Of them, 5 metabolites can be accumulative according to their linearly increasing tendency in vitro experiment. In addition, the proposed metabolic pathway demonstrated the primarily metabolites, i.e. dealkylated and hydroxylated metabolites were further transformed into secondary metabolites, i.e., aldehyde and carboxyl metabolites.
李建华, 张亚运, 孟维坤, 苏冠勇. 基于可疑筛查技术研究有机磷阻燃剂V6转化规律[J]. 中国环境科学, 2022, 42(9): 4409-4415.
LI Jian-hua, ZHANG Ya-yun, MENG Wei-kun, SU Guan-yong. Biotransformation of an organophosphate flame retardant V6 based on suspect screening technique. CHINA ENVIRONMENTAL SCIENCECE, 2022, 42(9): 4409-4415.
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